EXPLORING MUTATIONS IN THE GDF9 GENE FOR ENHANCED PROLIFICACY THROUGH BIOINFORMATICS ANALYSIS

Main Article Content

Saba Saeed
Shakeela Parveen
Muhammad Amir Iqbal
Jawaria Farooq
Amreen Naz

Keywords

GDF9, Mutations, Reproductive Traits

Abstract

This study comprehensively investigated sixteen mutations within the GDF9 gene in goats (Capra hircus), shedding light on their potential implications for goat reproduction. Utilizing bioinformatics tools, we analyzed the physicochemical properties, structural alterations, protein-protein interactions, and Gene Ontology (GO) associated with these mutations. The results revealed variations in molecular weight, instability index, and other physicochemical characteristics among the mutated GDF9 sequences. Structural modeling demonstrated subtle changes in functional domains induced by specific mutations. Protein-protein interaction network analysis unveiled close associations between GDF9 and key reproductive genes, emphasizing its central role in fertility. The study provides crucial insights for molecular breeding strategies aimed at enhancing goat prolificacy and reproductive performance. Understanding the genetic factors influencing goat reproduction is pivotal for developing targeted breeding approaches, ultimately contributing to sustainable and efficient livestock production. This research contributes to the growing body of knowledge surrounding the GDF9 gene in goats, offering a foundation for further exploration and practical applications in improving goat reproductive traits through molecular breeding.

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