BIOMEDICAL POTENTIAL OF STROBILANTHES GLUTINOSUS: EXPLORING ANTIMICROBIAL, ANTIOXIDANT, AND ENZYME INHIBITION
Main Article Content
Keywords
Antiinflammatory, Antioxidant, Medicinal plants, Antimicrobial, Enzyme Inhibition
Abstract
Strobilanthes glutinosus Nees, is a useful medicinal herb owing to its bioactive secondary metabolites. In this study the biomedical applications of leaf and stem extracts of S. glutinosus such as antimicrobial, antioxidant, antidiabetic, and anti-melanin activities (in vitro) and antiinflammatory activity (in vivo) were explored. Antibacterial and antifungal activities showed dose-dependent response against selective bacterial and fungal strains. The leaves and stem extracts showed better DPPH scavenging activity with IC50 value of 0.54 and 0.49 mg/ml respectively in comparison to standard ascorbic acid (0.76 mg/ml). Similarly, ABTS scavenging values of leaves, stem, and standard Trolox were 0.85, 0.32, and 2.55 µg/ml respectively. The S. glutinosus sample showed comparatively better α-amylase inhibition potential having IC50 values of 0.06 and 0.46 µg/ml by leaves and stem extract respectively vs acarbose (0.745 µg/ml). In the case of Tyrosinase inhibitory assay, the IC50 values of leaves, stem and standard Kojic acid were 5.924, 7.46 and 3.166 µg/ml. The leaf and stem extracts of S. glutinosus showed better anti-inflammatory activity in rabbits. Thus, S. glutinosus possesses great biomedical applications.
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Saadia Mehboob
Department of Biotechnology, Mirpur University of Science and Technology (MUST), 10250,
Mirpur AJK, Pakistan.
Hajra Hameed
School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen,
518060 P. R. China.
Muhammad Tariq
Department of Biotechnology, Mirpur University of Science and Technology (MUST), 10250,
Mirpur AJK, Pakistan.
Urwah Shafeeq
Department of Botany, University of Agriculture, Faisalabad, Pakistan.
Mahrukh Khattak
Department of Microbiology, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan.
Zulfiqar Ahmed
Department of Peds Surgery, Mohiuddin Teaching Hospital Mirpur AJK, New Industrial Area, D-4 W Rd, New Mirpur City, 10250, Pakistan.
Hammad Ismail
Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat, Pakistan.
Shagufta Sanam
Department of Microbiology, Shaheed Benazir Bhutto Women University, Peshawar, Pakistan.
Muhammad Bilal
Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University,
Islamabad, Pakistan.
Maaz Khan
Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University,
Islamabad, Pakistan.
Rehana Asghar
Department of Biotechnology, Mirpur University of Science and Technology (MUST), 10250,
Mirpur AJK, Pakistan.