CORRELATION OF LIPID PROFILE IN DIABETES PATIENTS: THE POTENTIAL FOR RISK REDUCING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE
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Keywords
Atherosclerotic Cardiovascular Disease, Diabetes, LDL, HDL
Abstract
Objectives:
To evaluate the efficacy of lipid therapy in mitigating the risk of Atherosclerotic Cardiovascular Disease (ASCVD) among individuals with Diabetes.
Materials and Methods: This was a prospective cohort study in which a total of 90 patients with DM were enrolled. This study was conducted at multiple centers including FG Polyclinic Hospital, NUST School of Health Sciences, Islamabad, CAT C Hospital Wari Dir Upper and LUMHS Jamshoro in the duration from March, 2023 to August, 2023. Participants had lipid profile tests to check total cholesterol, LDL, HDL, and Tg. Statin medication was prescribed for both existing and newly diagnosed high cholesterol. After six months, patients were followed to see if they developed atherosclerotic cardiovascular disease (ASCVD). For statistical analysis we used SPSS Version 25.
Results: In this study, 90 patients, with a mean age of 49.21 years, were enrolled. Their mean LDL cholesterol, HDL cholesterol, triglycerides, and total cholesterol levels were 113.9 mg/dL, 43.13 mg/dL, 124.6 mg/dL, and 191.04 mg/dL respectively. The mean HbA1C (%) value was 7.93. 15 patients (16%) developed ASCVD. There is week positive correlation between ASCVD and LDL cholesterol, HDL cholesterol and Triglycerides in DM patients with statin medication after 6 month.
Conclusion: It was concluded that individuals at high risk for heart disease could benefit from taking statins.
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Naveed Yaqoob
Associate Professor of Cardiology, FG Polyclinic Hospital, NUST School of Health Sciences, Islamabad
Azmatullah
Cardiologist (DIP Card NICVD Karachi), Medical Officer, CAT C Hospital Wari Dir Upper
Faisal Shehzad Roomi
Assistant Professor, Department of Cardiac Surgery, Chaudhary Pervaiz Elahi Institute of Cardiology Wazirabad, Punjab
Beenish Ghafar Memon
Assistant Professor Biochemistry, LUMHS Jamshoro
Fahad Asim
Senior Lecturer in Pharmacology & Therapeutics, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan
Shameem Nisar
Quality Assurance Manager, Rasco Pharmaceuticals, Lahore, Pakistan