CORRELATION OF LIPID PROFILE IN DIABETES PATIENTS: THE POTENTIAL FOR RISK REDUCING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Main Article Content

Naveed Yaqoob
Azmatullah
Faisal Shehzad Roomi
Beenish Ghafar Memon
Fahad Asim
Shameem Nisar

Keywords

Atherosclerotic Cardiovascular Disease, Diabetes, LDL, HDL

Abstract

Objectives:


To evaluate the efficacy of lipid therapy in mitigating the risk of Atherosclerotic Cardiovascular Disease (ASCVD) among individuals with Diabetes.


Materials and Methods:  This was a prospective cohort study in which a total of 90 patients with DM were enrolled. This study was conducted at multiple centers including FG Polyclinic Hospital, NUST School of Health Sciences, Islamabad, CAT C Hospital Wari Dir Upper and LUMHS Jamshoro in the duration from March, 2023 to August, 2023. Participants had lipid profile tests to check total cholesterol, LDL, HDL, and Tg. Statin medication was prescribed for both existing and newly diagnosed high cholesterol. After six months, patients were followed to see if they developed atherosclerotic cardiovascular disease (ASCVD). For statistical analysis we used SPSS Version 25.


Results: In this study, 90 patients, with a mean age of 49.21 years, were enrolled. Their mean LDL cholesterol, HDL cholesterol, triglycerides, and total cholesterol levels were 113.9 mg/dL, 43.13 mg/dL, 124.6 mg/dL, and 191.04 mg/dL respectively. The mean HbA1C (%) value was 7.93. 15 patients (16%) developed ASCVD. There is week positive correlation between ASCVD and LDL cholesterol, HDL cholesterol and Triglycerides in DM patients with statin medication after 6 month.


Conclusion: It was concluded that individuals at high risk for heart disease could benefit from taking statins.

Abstract 87 | Pdf Downloads 42

References

1. Vesa CM, Popa L, Popa AR, Rus M, Zaha AA, Bungau S, et al. Current data regarding the relationship between type 2 diabetes mellitus and cardiovascular risk factors. Diagnostics. 2020;10(5):314.
2. Amelia R, Sari Wahyuni A, Yunanda Y, Wijaya H. Atherosclerotic Cardiovascular Disease in Diabetes Patients. Current Diabetes Reviews. 2023;19(8):62-9.
3. Glovaci D, Fan W, Wong ND. Epidemiology of diabetes mellitus and cardiovascular disease. Current cardiology reports. 2019;21:1-8.
4. Nowbar AN, Gitto M, Howard JP, Francis DP, Al-Lamee R. Mortality from ischemic heart disease: Analysis of data from the World Health Organization and coronary artery disease risk factors From NCD Risk Factor Collaboration. Circulation: cardiovascular quality and outcomes. 2019;12(6):e005375.
5. Alzahrani SH, Baig M, Aashi MM, Al-Shaibi FK, Alqarni DA, Bakhamees WH. Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study. Diabetes, metabolic syndrome and obesity: targets and therapy. 2019:1639-44.
6. Federation I. IDF Diabetes Atlas, 9th edn. 2019.
7. Butool I, Nazir S, Afridi M, Shah SM. Evaluation and assessment of prescribing patterns in elderly patients using two explicit criteria based screening tools:(The PRISCUS list and STOPP/START criteria). Pakistan journal of medical sciences. 2018;34(6):1357.
8. Care D. Standards of medical care in diabetes 2019. Diabetes Care. 2019;42(Suppl 1):S124-38.
9. Chapman MJ, Zamorano JL, Parhofer KG. Reducing residual cardiovascular risk in Europe: Therapeutic implications of European medicines agency approval of icosapent ethyl/eicosapentaenoic acid. Pharmacology & therapeutics. 2022;237:108172.
10. Gonzalez-Jaramillo N, Wilhelm M, Arango-Rivas AM, Gonzalez-Jaramillo V, Mesa-Vieira C, Minder B, et al. Systematic review of physical activity trajectories and mortality in patients with coronary artery disease. Journal of the American College of Cardiology. 2022;79(17):1690-700.
11. Committee ADAPP, Committee: ADAPP. 10. Cardiovascular disease and risk management: Standards of Medical Care in Diabetes—2022. Diabetes care. 2022;45(Supplement_1):S144-S74.
12. Jagpal A, Navarro-Millán I. Cardiovascular co-morbidity in patients with rheumatoid arthritis: a narrative review of risk factors, cardiovascular risk assessment and treatment. BMC rheumatology. 2018;2(1):1-14.
13. Khalid MR, Lakho MA, Zubair M, Bhutto A, Abbas S, Yousif A. Correlation of lipid profile in diabetes patients: The potential for risk reducing of atherosclerotic cardiovascular disease.
14. Jayakumari C, Jabbar PK, Soumya S, Jayakumar R, Das DV, Girivishnu G, et al. Lipid profile in Indian patients with type 2 diabetes: the scope for atherosclerotic cardiovascular disease risk reduction. Diabetes Spectrum. 2020;33(4):299-306.

Most read articles by the same author(s)