THE RELATIONSHIP BETWEEN OBESITY AND SERUM ALBUMIN LEVELS IN ADULTS WITHOUT LIVER OR KIDNEY DYSFUNCTION

Main Article Content

Fida Hussain
Dr Kausar Abbas Saldera
Dr Rabail Irfan
Dr Ammara Naeem
Dr Abdullah Zia
Dr Muhammad Haider Ali
Muhammad Shahroz Khan
Fahad Asim

Keywords

Hypoalbuminemia, Serum Albumin, BMI, Obesity

Abstract

Objective: The objective of this study is to investigate the potential correlation between blood albumin levels and health complications associated with obesity in persons without any liver or kidney disorders.


Methodology: This study employed a cross-sectional design, using a sample of 160 individuals aged between 25 and 80 years. All participants were of the same gender. The participants were categorized into three distinct categories based on their body mass index (BMI): individuals with a healthy weight, overweight, and obese. Information was obtained regarding the individual's medical history, which may include a diagnosis of type 2 diabetes, physical ailments, and previous substance abuse. Venous blood samples were collected from the patient in order to determine the concentration of serum albumin. The study utilized SPSS 26.0 software to examine the correlation between hypoalbuminemia and obesity.


Results: Our study found no significant differences in the mean ages or gender distribution among normal-weight, overweight, and obese groups, with P-values of 0.125 and 0.172, respectively. While individuals in higher weight categories had a greater likelihood of developing diabetes, this difference was not statistically significant (P = 0.072). However, the prevalence of hypoalbuminemia was significantly higher in the overweight (29.8%) and obese (44.7%) groups compared to the normal-weight group (12.3%), with a P-value of 0.005. Additionally, median serum albumin levels were significantly lower in the overweight and obese groups compared to the normal-weight group (P < 0.001), indicating a strong association between increased body weight and reduced albumin levels.


Conclusion: The study reveals a substantial correlation between low blood albumin levels and being overweight. It is essential to accurately evaluate blood albumin levels in obese individuals to address obesity and provide effective nutrition management. Achieving a comprehensive global consensus on evaluation standards is crucial for these efforts, emphasizing the need for international cooperation and standardized guidelines in managing obesity-related hypoalbuminemia.

Abstract 29 | PDF Downloads 8

References

1. Guerreiro VA, Carvalho D, Freitas P. Obesity, Adipose Tissue, and Inflammation Answered in Questions. J Obes. 2022 Jan 22;2022:2252516. doi: 10.1155/2022/2252516. PMID: 35321537; PMCID: PMC8938152.
2. Hernandez JBR, Kim PY. Epidemiology Morbidity And Mortality. [Updated 2022 Oct 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547668/
3. Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015 May;50(3):117-128. doi: 10.1097/NT.0000000000000092. Epub 2015 Apr 7. PMID: 27340299; PMCID: PMC4890841.
4. Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. [Updated 2023 May 4]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK279167/
5. Beltrán-Carrillo VJ, Megías Á, González-Cutre D, Jiménez-Loaisa A. Elements behind sedentary lifestyles and unhealthy eating habits in individuals with severe obesity. Int J Qual Stud Health Well-being. 2022 Dec;17(1):2056967. doi: 10.1080/17482631.2022.2056967. PMID: 35356850; PMCID: PMC8979519.
6. Ginsberg HN, MacCallum PR. The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus. J Cardiometab Syndr. 2009 Spring;4(2):113-9. doi: 10.1111/j.1559-4572.2008.00044.x. PMID: 19614799; PMCID: PMC2901596.
7. Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017 May;183:57-70. doi: 10.1016/j.trsl.2017.01.001. Epub 2017 Jan 9. PMID: 28130064; PMCID: PMC5393930.
8. Fruh SM. Obesity: Risk factors, complications, and strategies for sustainable long-term weight management. J Am Assoc Nurse Pract. 2017 Oct;29(S1):S3-S14. doi: 10.1002/2327-6924.12510. PMID: 29024553; PMCID: PMC6088226.
9. Mosli RH, Mosli HH. Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure. Diabetes Metab Syndr Obes. 2017 Nov 8;10:467-472. doi: 10.2147/DMSO.S149832. PMID: 29184425; PMCID: PMC5687480.
10. Mun KH. Association Between Serum Albumin Levels and Obesity and Risk of Developing Chronic Kidney Disease Using Data from the Korean Multi-Rural Communities Cohort (MRCohort) Population Database. Med Sci Monit. 2021 Aug 16;27:e933840. doi: 10.12659/MSM.933840. PMID: 34398870; PMCID: PMC8378222.
11. Brock F, Bettinelli LA, Dobner T, Stobbe JC, Pomatti G, Telles CT. Prevalence of hypoalbuminemia and nutritional issues in hospitalized elders. Revista Latino-Americana de Enfermagem 2016 Aug; 24: e2736. doi: 10.1590/1518-8345.0260.2736.
12. Wiedermann, C.J. Hypoalbuminemia as Surrogate and Culprit of Infections. Int. J. Mol. Sci. 2021, 22, 4496. https://doi.org/10.3390/ijms22094496
13. Maqsood, M. ., Iram, H. ., Mariyam Haroon, S. ., Salman, S. ., Bhalli, A. ., & Iqbal, S. . (2022). Association Of Obese and Morbidly Obese Status with Hypoalbuminemia in Adults Without Liver and Kidney Disease: Obese and Morbidly Obese Status with Hypoalbuminemia in Adults . Pakistan Journal of HealthSciences,3(03).https://doi.org/10.54393/pjhs. v3i03.62

Most read articles by the same author(s)

1 2 > >>