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Inamullah Khan
Zaryaab Ahmad Khan
Saiqa Sumbal
Khushal Khan
Shehzad Alam Khan
Aamer Ahmad
Faizan Banaras



Background: Chronic Kidney Disease (CKD) poses a significant health burden globally, with hemodialysis (HD) and hemodiafiltration (HDF) being common renal replacement therapies. The Nephrology Division at Khyber Teaching Hospital, Peshawar, has observed a rising trend in the prevalence of CKD cases. This study aims to compare the efficacy and outcomes of HD and HDF in a cohort of 200 patients over a six-month duration, from January 2023 to June 2023.


Aim: The primary objective of this study is to evaluate and compare the clinical effectiveness of Hemodialysis and Hemodiafiltration in terms of patient outcomes, biochemical parameters, and quality of life in Nephrology patients at Khyber Teaching Hospital.


Methods: A prospective cohort study was conducted, enrolling 200 CKD patients undergoing renal replacement therapy. The sample was divided equally into two groups: 100 patients receiving Hemodialysis and 100 patients undergoing Hemodiafiltration. Data were collected on demographic characteristics, pre-dialysis and post-dialysis biochemical markers, dialysis adequacy, and adverse events. Quality of life assessments was conducted using standardized tools. Statistical analyses, including t-tests and chi-square tests, have been employed to compare the outcomes between the two groups.

Results: Preliminary findings have been presented, comparing the efficacy of Hemodialysis and Hemodiafiltration in terms of clearance rates, fluid removal, and biochemical parameter control. Additionally, the study will explore the impact of each modality on the patients' quality of life. Statistical significance and clinical relevance of observed differences has been discussed.


Conclusion: The study aims to provide valuable insights into the comparative effectiveness of Hemodialysis and Hemodiafiltration, aiding healthcare professionals in making informed decisions regarding renal replacement therapies. The outcomes will contribute to the existing body of knowledge in nephrology and may guide future advancements in CKD management. The findings of this research are crucial for optimizing treatment strategies and improving patient outcomes in the Nephrology Division at Khyber Teaching Hospital Peshawar.

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