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Sania Saleem
Mohammad Eyan Khan
Unaiza Nasir
Asma Rasool Peerzada
Muhammad Usman Babar
Faizan Banaras


SGLT-2 inhibitors, Gliflozins, cardiorenal outcomes, diabetes, cardiovascular health, chronic kidney disease, literature review, prospective cohort study, therapeutic options.


Background: Sodium-glucose co-transporter 2 inhibitors (SGLT-2 inhibitors or Gliflozins) have emerged as a class of drugs with potential benefits in both diabetic and non-diabetic patients. The impression of those agents on cardiorenal results in individuals with and without diabetes has been a subject of increasing interest and research. This study aims to explore and compare impacts of SGLT-2 inhibitors on cardiorenal health in these two distinct patient populations.

Aim: The main goal of our research is to explore cardiorenal outcomes in individuals having diabetes who are treated with SGLT-2 inhibitors, also in non-diabetic individuals who are prescribed these medications. The secondary aim is to discern potential differences in the mechanisms of action and therapeutic responses between diabetic and non-diabetic cohorts.

Method: A comprehensive literature review was conducted at Nephrology division Khyber Teaching Hospital (KTH) Peshawar from April 2022 to march 2023 in order to get existing research on SGLT-2 inhibitors and their impact on cardiorenal health. In addition, a prospective cohort study was carried out, including patients with and without diabetes, who were prescribed SGLT-2 inhibitors. Clinical, biochemical, and imaging data were collected, and cardiorenal endpoints such as cardiovascular events, kidney function, and quality of life were assessed. Statistical studies were achieved to compare outcomes between diabetic and non-diabetic groups.

Results: Subgroup studies were performed to investigate whether impact of SGLT-2 inhibitors on cardiorenal outcomes varied based on specific patient characteristics such as age, gender, and baseline eGFR. The research involved the overall 200 respondents, divided into two sets: these having diabetes (n=100) and those without diabetes (n=100).

Conclusion: SGLT-2 inhibitors, commonly known as Gliflozins, have shown promising results in improving cardiorenal results in both diabetic and non-diabetic patients. Their use should be considered as a therapeutic option beyond diabetes management, especially in patients at danger of cardiovascular and renal problems. Additional research is required to clarify precise mechanisms responsible for these effects and to optimize treatment strategies.


Keywords: ,, ,, , , , , 

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