ROLE OF PHYSALIS PERUVIANA IN COMBINATION WITH TAMOXIFEN IN DECREASING ANXIETY AND DEPRESSION IN RATS WITH DIMETHYLBENZ(A)ANTHRACENE (DMBA) INDUCED BREAST CANCER
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Keywords
Physalis Peruviana, Breast Cancer, Tamoxifen resistance, Anxiety, Depression
Abstract
Background: Physalis Peruviana has neuroprotective effects on anxiety and depression induced by Cancer. Psychosocial variables may influence breast cancer susceptibility and prognosis.
Objective: This research aims to evaluate the efficacy of Physalis Peruviana fruit extract in anxiety and depression due Breast cancer induced by DMBA in Albino rats.
Materials and Methods: The 60 female albino rats used in this study were divided into 05 groups and induced with tumor and treated for 10 weeks at Liaquat University of Medical and Health Sciences, Jamshoro.
Results: Rats in Group E demonstrated improving activity and reduction in depression and anxiety.
Conclusion: The Physalis Peruviana extract has neuroprotective effects on depression and anxiety.
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Fahmida Gul
Lecturer of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro.
Samreen Memon
Professor of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro
Ikramuddin Ujjan
Professor of Pathology, Liaquat University of Medical & Health Sciences Jamshoro,
Kanwal Abbas Bhatti
Associate Professor Medicine, Department Liaquat University Hospital Jamshoro.
Pushpa Goswami
Professor of Anatomy, Liaquat University of Medical & Health Sciences, Jamshoro.
Waseemullah Shaikh
Lecturer of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro.