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Sundas Asad
Eslam Mohammed Shalaby
Niaz Hussain Keerio
Zulfiqar Haider Kerawala
Mohammed Asif Peracha
Azizullah Bhayo


Platelet-Rich Plasma (PRP), knee arthritis, osteoarthritis, effectiveness


Background: Osteoarthritis is a disorder that mainly affects the cartilage in synovial joints, resulting in localized damage and sclerosis of the subchondral bone. It is the most prevalent type of joint disease worldwide and is closely linked to aging. The World Health Organization (WHO) states that osteoarthritis is the primary cause of severe, persistent pain and physical disability, affecting a large number of people worldwide. Platelet-Rich Plasma, (PRP), is a concentrated form of human platelets that is higher than the body's typical platelet count. PRP has been used in surgical procedures since 1987 to promote cell regeneration, and a significant amount of evidence supports its efficaciousness as a treatment for tendinosis.

Objective: To ascertain the effectiveness of platelet-rich plasma (PRP) in the early stages of knee articular arthritis.

Study design: A cross-sectional study

Place and Duration: This study was conducted in Peoples Medical College & Hospital Nawabshah from July 2022 to July 2023

Methodology: There were a total of 150 people involved in this study, and this sample was calculated using a non-probability convenient sampling technique. The participants of this study were those who were diagnosed with early knee osteoarthritis. A 30–40 cc venous blood sample was taken from the ante-cubital vein and put in a sterile tube containing anticoagulant dextrose solution A (ACDA) in order to create 4-5 cc of Platelet-Rich Plasma (PRP) with a platelet concentration 4-6 times greater than the normal values. WOMAC and VAS scores were used to evaluate the outcomes. SPSS version 20 was used to analyze the data. A p-value of less than 0.05 was considered significant.

Results: There are a total of 150 participants in this research. Out of these 150 people, there were 108 (72%) females, and the rest 42 were males. The mean age of the participants was 56.14 years. The average weight of the participants was 84.24 kg. Overall, 132 people had difficulty sitting on the floor. A total of 78 people had the right joint involvement. The mean VAS score before PRP was 7.21, and at 6 months, it was 5.12. A total of 74 patients had a satisfactory outcome, 46 participants had a fair outcome, and 30 people had a poor outcome.

Conclusion: One economical and minimally intrusive way to treat early-stage degenerative knee joint cartilage lesions is to use Platelet-Rich Plasma (PRP).

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