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Safia Abidi
Nihal Fatima
Tayyaba Mumtaz
Sidra Farooq
Hira Naeem
Marium Tariq
Sumreen Mujahid


Grape seed extract, Cranberry fruit extract, Methicillin resistant Staphylococcus aureus, Antibiotic resistance, Meropenem, Linezolid.


Objective: The investigation is designed to assess the combination of grape seed and cranberry extracts against MRSA through a synergistic effect.

Methodology: This in vitro study used clinical MRSA isolates for analysis. Grape seed and cranberry extracts were prepared at different concentrations, and their antibacterial capabilities were assessed using agar dilution techniques. The resulting zones of inhibition were measured for analysis.

Results: The study revealed that both Cranberry Fruit Extract (CFE) and Grape Seed Extract (GSE) demonstrated significant antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA) at various concentrations, even at the lowest concentration of 20mg/ml it showed a considerable 80% sensitivity rate and minimal resistance. The combination of CFE and GSE at different concentrations demonstrated outstanding antibacterial efficacy against MRSA, reaching 100% sensitivity at the highest concentration, surpassing common antibiotics like Meropenem. This combination exhibits great potential for clinical use in the fight against MRSA infections.

Conclusion: As antibiotic resistance continues its relentless ascent, the exploration of natural alternatives like grape seed and cranberry extracts becomes increasingly critical. These extracts not only demonstrate individual promise in combating MRSA but also exhibit the enticing potential for a synergistic effect when deployed together. Amid the pressing global concern over antibiotic resistance, these natural alternatives emerge as promising weapons in our arsenal against bacterial infections.

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