CURRENT MANAGEMENT AND TREATMENT OF CROHN'S DISEASE

Main Article Content

Camila Córdova Salazar
Manuel Rafael Aldas Erazo

Keywords

Crohn's disease, Inflammatory bowel disease, Management, Treatment

Abstract

Crohn's disease (CD) is a chronic inflammatory condition that affects the digestive system whose incidence and prevalence has been increasing in recent years. This pathology has been considered idiopathic, however in recent years it has been seen that it has a close relationship with genetic predisposition. Not knowing it's etiology can generate controversies about which treatment is the most appropriate for solving the objectives, however the treatment focuses on the use of monoclonal antibodies, immunomodulators and even surgical procedures. It is of utmost importance to establish a close doctor-patient relationship in this pathology given the persistence of episodes of remission and relapses.


Objective: To describe the updated management and treatment of Crohn's disease.


Materials and Methods: A review of narrative literature with a qualitative approach was carried out by searching the literature in electronic scientific databases such as PubMed, VHL, Redalyc, Science Direct, Cochrane. The search strategy was using specific MESH terms and manual keywords as follows: (UPDATE) AND (MANAGEMENT) OR (USE) AND (TREATMENT) AND (CROHN'S DISEASE) OR (INFLAMMATORY BOWEL DESEASE). After the initial search, 822 studies were located, in which 781 articles that were not relevant to the objective of this review were excluded after reviewing the abstract, so we worked with 41 selected articles


Results: A total of 41 articles selected through abstract review were used. In the update of the management of the disease, various treatments have been developed aimed at controlling the outbreak and keeping the patient under review through a multidisciplinary approach.


Conclusions: The choice of the appropriate treatment for CD is based on multiple factors such as the demographics of the individual, the severity of the disease, and the existence of complications. In this context, doctors need to be up-to-date and familiar with each therapy in order to provide optimal advice to their patients. However, in recent decades, the management of these patients has presented several therapeutic alternatives available, including monoclonal antibody therapies, immuno- modulators, and surgery.

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