FORMULATION, CHARACTERIZATION AND CLINICAL INVESTIGATION OF CORDIA MYXA EXTRACT LOADED EMULSION FOR UV PROTECTION AND ANTI-AGING POTENTIAL

Main Article Content

Ammara Choudhry
Mudassar Mazher
Muhammad Shahzad Khan
Hosh Muhammad Lashari
Umer Shaukat
Sidra
Aqna Malik
Muhammad Yousuf
Zafar Iqbal
Abdul Qudoos
Qazi Adnan
Maham Amjad
Zahara Razzaq
Aisha Sethi

Keywords

Cordia myxa extract, Antioxidant, Sun Protection Factor (SPF), Skin Elasticity, Anti-inflammatory, Photo-aging

Abstract

Phyto-constituents from Cordia myxa (CM) demonstrate anti-inflammatory, UV protection and anti-aging properties due to its mucilage contents. However, incorporation and stabilization of Cordia myxa extract into a suitable delivery system has always been a challenge. To overcome, this study aimed to formulate a topical formulation, preferably emulsion, characterize its physicochemical properties, quantify its sun protection factor, investigate its effects on skin physical parameters, and evaluate its anti-aging potential, extraction and phyto-chemical analysis of CM extract. Cordia myxa (CM) extract loaded emulsion was formulated and characterized. The Cordia myxa plant extract exhibited anti-oxidant eventual (86.26±1.005% DPPH inhibition), Phenolic contents (214.38±0.412 mg of GAE/g extract), and Flavonoid contents (46.01±0.47 µg of QE/mg of extract) while the extract loaded emulsion demonstrated a sun protection factor of 17. Formulation showed stability in terms of organoleptic, pH, microscopy, and rheological investigations. Non-invasive in vivo investigations on 13 healthy volunteers showed significant improvements in skin elasticity and hydration while the skin erythema and melanin contents were reduced.

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