APPLICATION OF ETHANOL-INJECTION TECHNIQUE FOR FORMULATION OF VITEXIN LOADED NOISOMES AND CHARACTERIZATION OF THE VESICLES

Main Article Content

Pushpendra Kumar
Kapil Malviya
Pushpendra Soni
Lavakesh Kumar Omray

Keywords

Vitexin, inflammation noisome, ethanol-injection, entrapment

Abstract

In the present study niosomes of vitexin were developed by ethanol injection method and were characterized for particle size, entrapment and drug release and release kinetics. The niosomes prepared using either span 60, tween 80 or tween 20 as the non-ionic surfactants and cholesterol as the lipid were evaluated for particle size, entrapment efficiency and in vitro release. Increasing the HLB value of the surfactant was found to increase the particle size of the vesicles. On the other hand, surfactant with lower HLB also exhibited better entrapment efficiency. The entrapment efficiency of the formulations was found to be in the range of 55 – 71%. The release of vitexin from the prepared niosomes ranged from 60.78 % to 76.37%. Formulation F3 presented the lowest particles size (229.6 nm), higher entrapment efficiency (71%) and sustained release of vitexin over 24 hours (65.53) and was considered the best formulation.  The release of vitexin from the F3 depicted Higuchi and Korsemeyer-Peppas type of mechanism at these two models presented higher linearity compared to the first-order and zero-order models

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