Adverse Effects in Neonates Exposed to SSRIs and SNRI in Late Gestation

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Gideon Koren
Nina Boucher


Neonates, SSRIs, SNRI, Late Gestation


Neonates exposed at term to selective serotonine (SSRI) or serotonine-norepinephrine reuptake inhibitors (SNRI) medications may encounter symptoms such as irritability, rigidity, tremor and respiratory distress. Most available data suggest that these self limited symptoms are due to discontinuation  of  the  drug, although  there  are documented cases of symptoms associated with high serum concentrations in the neonate that subsided when levels fall. Preliminary evidence suggests that the very early respiratory symptoms may not be part of discontinuation but rather part of a reversible form of persistent pulmonary hypertension of the newborn (PPHN).

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