EFFECT OF VOCATIONAL THERAPY ON THE IMPROVEMENT OF COGNITIVE FUNCTION AND INTERLEUKIN LEVELS 17 IN SCHIZOPHRENIC PATIENTS RECEIVING RISPERIDONE
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Keywords
Schizophrenia,, Vocational Therapy, Cognitive Function, IL-17, Risperidone
Abstract
Background – Schizophrenia is a severe mental disorder in which chronic inflammation is one of the causes. Schizophrenia can affect the cognitive function of sufferers, therefore the management must be comprehensive by combining pharmacological and non-pharmacological therapies. Risperidone therapy combined with vocational therapy was thought could improve cognitive function in schizophrenic patients and was associated with changes in IL-17 levels. Aim – To determine the effect of vocational therapy in improving cognitive function and IL-17 levels in schizophrenic patients receiving risperidone.
Method – Pre and post-test experimental analysis with non-random group selection. The number of subjects were 28 schizophrenic patients who were evenly divided into 2 groups, namely the treatment group receiving risperidone 2-6 mg/day with 8 weeks vocational therapy and the control group receiving only 2-6 mg risperidone/day. MoCA-Ina was cold to measure the cognitive function and the levels of IL-17. Comparison and correlation tests were performed between groups.
Results – Vocational therapy had an effect on improving cognitive function in both groups (p 0.000). However, in the treatment group who received a combination of risperidone 2-6 mg/day and 8 weeks of vocational therapy had a better result.
Conclusion – Vocational therapy for 8 weeks with by risperidone therapy 2-6 mg/day could improve cognitive function in schizophrenic patients. Vocational therapy for 8 weeks did not affect IL-17 levels. There is no correlation between the improvement of cognitive function in schizophrenic object with changes in IL-17 levels experienced.
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Sonny T Lisal
Department of Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Perintis Kemerdekaan Road, Km. 10, Tamalanrea, Makassar, South Sulawesi, Indonesia, 90245,
Musta’ina
Department of Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
Andi Jayalangkara Tanra
Department of Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
Burhanuddin Bahar
Department of Public Health, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia.
Erlyn Limoa
Department of Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia.
Andi Tenri Esa
Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
Saidah Syamsuddin
Department of Psychiatry, Faculty of Medicine, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia.