Efficacy Of Supplementary Melatonin as Adjunct to Surgical Periodontal Therapy on Periodontal Parameters: A Pilot Study

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Iram Rafique Pawane
Sankari Malaiappan


Dysbiosis, Inflammation, Melatonin, Periodontal disease


Aim: To evaluate the effect of two dosages of systemically administered melatonin compared to a placebo on clinical parameters in adjunct to regenerative surgical periodontal therapy.
Material And Methods: 30 subjects with Stage III Grade A/B periodontal disease indicated for surgical periodontal therapy were recruited. Group I received 3mg melatonin (n=10), group II received 6 mg melatonin (n=10) and the control group received a placebo (n=10), once a day, for one month. Clinical parameters assessed: Probing Depth (PD), Clinical Attachment Levels (CAL), Gingival Index (GI) and Plaque Index (PI) evaluated at 3 months from baseline. Obtained data analysis done using SPSS software version 23 (Statistical Package for the Social Sciences, SPSS, version 21). Data normality tested using Shapiro-Wilk and Kolmogrov Smirnov tests. One way Anova test was done for intergroup analysis, paired-t test was used to compare all the parameters between different time intervals within each group. In all the tests, the p value of < 0.05 was considered to be statistically significant.
Results: All groups showed significant improvement at follow up in the intra-group analysis on all clinical outcomes. A one-way ANOVA test was performed to evaluate the effect on clinical outcomes between each group. Tukey’s HSD comparisons found a statistically significant difference in both intervention groups compared to placebo in PD reduction and gingival index values (p< 0.05). However, 6 mg melatonin was seen to have higher differences compared to 3mg melatonin and placebo group in CAL outcomes.
Conclusion: Oral administration melatonin after surgical periodontal management resulted in significant improvement in clinical parameters. 6mg melatonin was more effective in improving clinical parameters compared to 3mg melatonin. However, further studies involving a longer follow up period would be desirable to substantiate the current results.

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