Design, Synthesis, And Characterization of Some New Schiff Bases Derivatives for Piperidine, 3-Amino-1,2,4-Triazole-5-Thiolate Salt and Biological Evaluation as Antibacterial Agents

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Abeer Hussein Ali
Mukhlif Mohsin Slaihim


3-amino-1,2,4-triazole-5-thiol, Piperidinium salt, Schiff base, antibacterial activity


Schiff bases (MP1-MP10) were synthesized by reacting various benzaldehyde derivatives with 3- amino-1,2,4-triazole-5-thiol in the presence of piperidine, and all compounds were identified using spectroscopy. UV, FIR, GC-Mass, and HNMR for some combinations, as well as measuring melting points. The obtained results matched the suggested structures of the newly synthesized compounds. All prepared compounds (MP1-MP10) were tested for biological activity against four types of Grampositive and Gram-negative bacteria at seven concentrations. The study found that the compound MP1 inhibited all types of bacteria in the first four concentrations.

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