RELATIONSHIP BETWEEN THYROID DYSFUNCTION, OXIDATIVE STRESS, AND ATHEROGENIC LIPID MARKERS: A COMPARATIVE STUDY
Main Article Content
Keywords
TFT, MDA, TAC, CRP
Abstract
Background:
Thyroid dysfunction, particularly hypothyroidism, is associated with metabolic disturbances that may increase cardiovascular risk. Altered thyroid hormone levels influence lipid metabolism, oxidative balance, and inflammatory pathways. This study aimed to evaluate the relationship between thyroid dysfunction, oxidative stress, and atherogenic lipid markers in comparison with healthy individuals.
Methods:
This comparative cross-sectional study included 500 participants divided into two groups: hypothyroid patients (n = 250) and age- and sex-matched euthyroid controls (n = 250). Thyroid function tests (TSH, fT3, fT4), lipid profile parameters, apolipoproteins, lipoprotein(a), oxidative stress markers (malondialdehyde [MDA], total antioxidant capacity [TAC]), nitric oxide (NO), and CRP were assessed. Intergroup comparisons were performed using Student’s t-test, and Pearson’s correlation analysis was used to evaluate associations between TSH and biochemical variables.
Results:
Hypothyroid patients exhibited significantly higher BMI (p < 0.001) and a markedly atherogenic lipid profile, characterized by elevated total cholesterol, triglycerides, LDL-C, lipoprotein(a), and Apo-B, along with reduced HDL-C and Apo-A1 (p < 0.001). Total antioxidant capacity was significantly reduced, while MDA levels were elevated in the hypothyroid group (p < 0.001), indicating increased oxidative stress. A greater proportion of hypothyroid patients demonstrated elevated hs-CRP levels, reflecting heightened inflammatory status. Correlation analysis revealed significant associations between TSH and oxidative as well as atherogenic lipid markers in the hypothyroid group.
Conclusion:
Hypothyroidism is associated with dyslipidemia, oxidative stress, and systemic inflammation, suggesting an integrated mechanism contributing to increased cardiovascular risk. Comprehensive metabolic and inflammatory assessment may be essential in the clinical management of patients with thyroid dysfunction.
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Pooja rathore
Ph.D Scholar, Dept.of Biochemistry, Malwanchal University,Indore
