EVALUATE THE EFFICACY OF PREEMPTIVE INTRAVENOUS IBUPROFEN ON POSTOPERATIVE ANALGESIA AND INTRAOPERATIVE HEMODYNAMIC STABILITY AND RECOVERY IN ENT SURGERIES: A PROSPECTIVE,RANDOMIZED, DOUBLE BLINDED PLACEBO-CONTROLLED STUDY.
Main Article Content
Keywords
Dexmedetomidine, Pneumoperitoneum, Cholecystectomy, Analgesia
Abstract
To evaluate the efficacy of pre-emptive intravenous (IV) ibuprofen on postoperative analgesia by assessing pain parameters, specifically: The time to administration of the first rescue analgesic.
Material and Methods: This prospective randomized double blind, placebo-controlled study done in department of Anaesthesia at Ananta Institute of Medical Sciences and Research Centre, during one and half year after approval from Institutional Ethical Committee, with sample size of Sixty-six patients undergoing ENT surgeries.
Results: Right tympanoplasty was more common than left. Most patients were ASA I or II; none were ASA III. All patients underwent general anesthesia. Significantly lower HR, SBP, DBP, and MAP in the Ibuprofen+Fentanyl group (p < 0.05).Continued significantly lower HR, SBP, DBP, and MAP in the Ibuprofen+Fentanyl group (p < 0.05).Postoperative VAS scores were significantly lower at all measured time points in the Ibuprofen+Fentanyl group (p < 0.05). First rescue analgesia needed at 24 hours in the Ibuprofen+Fentanyl group vs. 12 hours in the Fentanyl-only group. Both groups maintained mean SpO of 100% throughout. Overall opioid consumption was lower in the Ibuprofen+Fentanyl group. No significant adverse events were reported in either group.
Conclusion: The results demonstrate that a higher dose of dexmedetomidine (0.6 µg/kg/h) provides better intraoperative and postoperative hemodynamic stability, superior analgesia, and effective sedation compared to a lower dose (0.3 µg/kg/h). However, the increased incidence of bradycardia and hypotension in the higher dose group necessitates vigilant monitoring and appropriate management.
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Dr Ajeet Kumar Dev
Junior Resident, Department of Anaesthesia, Ananta Institute of Medical Sciences and Research Centre, Rajsamand,
Dr Deependar Kumar Adarshi
Junior Resident, Department of Anaesthesia, Ananta Institute of Medical Sciences and Research Centre, Rajsamand,
Dr Adnan Naim
Junior Resident, Department of Anaesthesia,RIMS,Ranchi.
