COMPARISON OF EFFICACY OF TWO DIFFERENT DOSES OF DEXMEDETOMIDINE ON THE HAEMODYNAMIC PARAMETERS OF PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY:A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY
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Keywords
Dexmedetomidine, Pneumoperitoneum, Cholecystectomy, Analgesia
Abstract
To compare the effects of two different doses of Dexmedetomidine infusion (0.3μg/kg/hour and 0.6μg/kg/hour) on hemodynamic parameters (SBP, DBP, MAP, HR and SPO2) during Laryngoscopy, intubation and pneumoperitoneum in patients undergoing laparoscopic cholecystectomy
Material and Methods: This prospective, randomized, double-blind study was conducted in the Department of Anaesthesia at a tertiary care hospital over one and a half years following approval from the Institutional Ethics Committee with sample size of 70 (35 in each group).
Results: Group 2 demonstrated significantly better intraoperative hemodynamic stability. This included lower and more consistent HR and SBP, especially during key stress-inducing events such as intubation, pneumoperitoneum. Postoperatively, Group 2 maintained superior hemodynamic stability, with lower HR and SBP over a 24-hour period compared to Group 1. Group 2 exhibited higher sedation scores immediately postoperatively, but sedation levels became comparable between groups within 4 hours.Patients in Group 2 reported significantly lower VAS scores, indicating better pain control. Group 2 experienced a higher incidence of adverse events, notably bradycardia (22.9% vs. 8.6%) and hypotension (20.0% vs. 5.7%)
Conclusion: The results demonstrate that a higher dose of dexmedetomidine (0.6 µg/kg/h) provides better intraoperative and postoperative hemodynamic stability, superior analgesia, and effective sedation compared to a lower dose (0.3 µg/kg/h). However, the increased incidence of bradycardia and hypotension in the higher dose group necessitates vigilant monitoring and appropriate management.
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Dr Deependar Kumar Adarshi
Junior Resident, Department of Anaesthesia, Ananta Institute of Medical Sciences and Research Centre, Rajsamand,
Dr Ajeet Kumar Dev
Junior Resident, Department of Anaesthesia, Ananta Institute of Medical Sciences and Research Centre, Rajsamand,
Dr Adnan Naim
Junior Resident, Department of Anaesthesia,RIMS,Ranchi.
