PAIN RESPONSE TO M-M-R VACCINATION IN 4 - 6 YEAR OLD CHILDREN
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Keywords
Vaccination, pain, measles-mumps -rubella vaccine
Abstract
Background
Differences in pain response to two different M-M-R products have previously been demonstrated in 12-month old infants and in 4 – 6 year old children.
Objective
To determine if the acute and immediate pain response to two licensed M-M-R vaccine products (using a self-report measure) in children 4-6 years of age was similar to that demonstrated in younger infants.
Methods
Randomized, double blind, study. Subjects were randomly allocated to Priorixâ (SmithKline Beecham) or M-M-R IIâ (Merck Frosst). The primary outcome measure was pain response to vaccination quantified using a self-report OUCHER pain scale. Secondary outcome measures included pain measurement by proxy (physician and parent) using a visual analog scale (VAS) and measurement of cry and cry duration immediately post-vaccination.
Results
Of the 60 subjects enrolled, 30 received Priorixâ and 30 received M-M-R IIâ. There were no significant differences between the two groups on age, sex, or previous painful procedure. Post-vaccination, children in the M-M-R IIâ group had higher median pain scores comp ared with children in the Priorixâ group for VAS (12.5 vs. 2.0, respectively by paediatricians, p=0.017; 18.5 vs. 5.0, respectively by parents, p=0.235), OUCHER (20 vs. 0.00, respectively, p=0.047). The median duration of crying post M-M-R IIâ was higher compared with Priorixâ (6 vs. 0 seconds, respectively, p=0.020).
Conclusion
Priorixâ was associated with significantly less pain compared with M-M-R IIâ, at the time of injection.
References
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