LEVELS OF HDL CHOLESTEROL IN ISCHEMIC STROKE PATIENTS AND DISEASE OUTCOME IN 2 WEEKS
Main Article Content
Keywords
HDL cholesterol, ischemic stroke, lipid profile, neurological outcome, prognosis
Abstract
: Ischemic stroke remains a significant factor leading to disabilities and death, and new research indicates that lipid disorders, mainly low HDL cholesterol, might be a determining factor for the extent of stroke and the patient's recovery within the first hours.
Objective: To find out the level of HDL cholesterol in patients with an ischemic stroke and measure the relationship of these levels with the clinical outcomes after two weeks.
Methods: This observational study was carried out at HBS Medical and Dental College Islamabad, from September 2024 to February 2025. Patients aged 18 years and above with a confirmed diagnosis of ischemic stroke were included in the study. HDL-C, along with other lipid parameters, was checked within 24 hours of the patient's admission. Neurological status was determined with the aid of NIHSS, and the two-week results were measured through the modified Rankin Scale (mRS). Statistical analyses comprised group comparisons and logistic regression.
Results: Elevated HDL-C levels were very significantly linked to positive outcomes at two weeks. Individuals who experienced bad recovery were found to have substantially lower levels of HDL-C, and the regression analysis revealed that HDL-C was the only predictor of early functional improvement.
Conclusion: HDL cholesterol represents one of the significant prognostic factors in the first phase of ischemic stroke recovery.
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Dr Syed Hur Hussain Hamdani
Senior Registrar Medicine, HBS Medical and Dental College Islamabad