COMPREHENSIVE STUDY ON PHARMACOLOGICAL BENEFITS OF LYCOPENE IN THE PREVENTION AND TREATMENT OF AGING AND AGE-RELATED AILMENTS
Main Article Content
Keywords
Lycopene, Pharmacological, Aging, Neurodegenerative Disease, Therapeutics
Abstract
The process of ageing and associated chronic diseases are significant contributors to global death rates. The incidence of these disorders is steadily and universally rising. Given the continuous increase in the worldwide burden, it is essential to explore alternate approaches to conventional treatment to mitigate the risk of age-related disorders. Lycopene, a carotenoid pigment, is abundantly found in several fruits and vegetables, including tomatoes, grapefruits, and watermelons. It possesses a distinctive molecular configuration that imparts robust antioxidant characteristics. This nutraceutical exhibits various anti-aging attributes, including the mitigation of age biomarkers and the improvement of some chronic illnesses. A thorough review to assess the efficacy of lycopene in mitigating ageing progression and age-related chronic disorders has yet to be conducted. This review analyses prior pre-clinical, clinical, and epidemiological studies on lycopene to assess its efficacy in addressing age-related disorders and its function as a calorie restriction mimic. Research has shown that diets rich in lycopene can aid in the prevention or reduction of age-related illnesses. This review indicates that lycopene may be employed in therapeutic contexts to enhance human health and alleviate the onset of ageing and age-related disorders, as supported by current findings.
References
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5. Bhuvaneswari, V., Velmurugan, B., & Nagini, S. (2002). Induction of glutathione-dependent hepatic biotransformation enzymes by lycopene in the hamster cheek pouch carcinogenesis model. Journal of Biochemistry, Molecular Biology, and Biophysics, 6(4), 257–260. https://doi.org/10.1080/10258140290030843
6. Blackburn, E. H. (1991). Structure and function of telomeres. Nature, 350(6319), 569–573. https://doi.org/10.1038/350569a0
7. Blackburn, E. H. (2005). Telomeres and telomerase: Their mechanisms of action and the effects of altering their functions. FEBS Letters, 579(4), 859–862. https://doi.org/10.1016/j.febslet.2004.11.036
8. Blanpain, C., & Fuchs, E. (2006). Epidermal stem cells of the skin. Annual Review of Cell and Developmental Biology, 22(1), 339–373. https://doi.org/10.1146/annurev.cellbio.22.010305.104357
9. Boileau, T. W. M., Liao, Z., Kim, S., Lemeshow, S., Erdman, J. J. W., & Clinton, S. K. (2003). Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. Journal of the National Cancer Institute, 95(21), 1578–1586. https://doi.org/10.1093/jnci/djg081
10. Boyacioglu, M., Kum, C., Sekkin, S., Yalinkilinc, H. S., Avci, H., Epikmen, E. T., & Karademir, U. (2016). The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats. Clinical Nutrition, 35(2), 428–435. https://doi.org/10.1016/j.clnu.2015.03.006
11. Cao, Z., Wang, P., Gao, X., Shao, B., Zhao, S., & Li, Y. (2019). Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat. Journal of Inorganic Biochemistry, 193, 143–151. https://doi.org/10.1016/j.jinorgbio.2019.01.017
12. Cataño, J., Trujillo, C., Caicedo, J., Bravo-Balado, A., Robledo, D., Mariño-Alvarez, A., Pedraza, A., Arcila, M., & Plata, M. (2018). Efficacy of lycopene intake in primary prevention of prostate cancer: A systematic review of the literature and meta-analysis. Archivos Españoles de Urología, 71, 187–197.
13. Celik, H., Kucukler, S., Ozdemir, S., Comakli, S., Gur, C., Kandemir, F. M., & Yardim, A. (2020). Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology, 80, 29 40. https://doi.org/10.1016/j.neuro.2020.06.005
14. Chernyshova, M. P., Pristenskiy, D. V., Lozbiakova, M. V., Chalyk, N. E., Bandaletova, T. Y., & Petyaev, I. M. (2019). Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study. Journal of Dairy Science, 102(1), 14–25. https://doi.org/10.3168/jds.2018-15282
15. Dai, C., Tang, S., Deng, S., Zhang, S., Zhou, Y., Velkov, T., Li, J., & Xiao, X. (2015). Lycopene attenuats colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway. Antimicrobial Agents and Chemotherapy, 59(1), 579–585. https://doi.org/10.1128/aac.03925-14
16. Davies, D. F., & Shock, N. W. (1950). Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. The Journal of Clinical Investigation, 29(5), 496–507. https://doi.org/10.1172/jci102286
17. Dogukan, A., Tuzcu, M., Agca, C. A., Gencoglu, H., Sahin, N., Onderci, M., Ozercan, I. H., Ilhan, N., Kucuk, O., & Sahin, K. (2011). A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression. Nutrition and Cancer, 63(3), 427–434. https://doi.org/10.1080/01635581.2011.535958
18. El-Gerbed, M. S. (2014). Protective effect of lycopene on deltamethrin-induced histological and ultrastructural changes in kidney tissue of rats. Toxicology and Industrial Health, 30(2), 160–173. https://doi.org/10.1177/0748233712448115
19. Ellis, A. C., Dudenbostel, T., & Crowe-White, K. (2019). Watermelon juice: A novel functional food to increase circulating lycopene in older adult women. Plant Foods for Human Nutrition, 74(2), 200–203. https://doi.org/10.1007/s11130-019-00719-9
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Maharabam Anandi Devi. (2025). COMPREHENSIVE STUDY ON PHARMACOLOGICAL BENEFITS OF LYCOPENE IN THE PREVENTION AND TREATMENT OF AGING AND AGE-RELATED AILMENTS. Journal of Population Therapeutics and Clinical Pharmacology, 28(01), 444-461. https://doi.org/10.53555/v7ggzp20
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Author Biography
Maharabam Anandi Devi
Department of Biochemistry, Manipur College, Imphal, Manipur, India,
How to Cite
Maharabam Anandi Devi. (2025). COMPREHENSIVE STUDY ON PHARMACOLOGICAL BENEFITS OF LYCOPENE IN THE PREVENTION AND TREATMENT OF AGING AND AGE-RELATED AILMENTS. Journal of Population Therapeutics and Clinical Pharmacology, 28(01), 444-461. https://doi.org/10.53555/v7ggzp20