INFLUENCE OF OBESITY AND LIFESTYLE FACTORS ON FEMALE INFERTILITY: A STUDY AT KHYBER TEACHING HOSPITAL PESHAWAR

Main Article Content

Dr Laila Hussain
Dr Sumbal Afridi
Dr Reema Fateh
Dr Farrukh Gul
Dr Sundus Rahman
Dr Rahat Bibi

Keywords

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Abstract

Background: There is growing recognition that obesity and other lifestyle determinants are essential causes of infertility in women. Increased prevalence of obesity in women of reproductive age is a health issue of concern to the general population, especially in less-developed and middle-income countries.


Objective: To assess how obesity and lifestyle habits relate to infertility in women being treated in Khyber Teaching Hospital in Peshawar, and the metabolic and hormonal risk factors associated with this association.


Methods: The present cross-sectional descriptive study was carried out at Gynae & Obs Department, MTI Khyber Teaching Hospital Peshawar, Pakistan from 1st January, 2025 to 30th June, 2025. Two hundred and fifty women between the ages of 18 and 45 years were recruited with primary or secondary infertility. Structured questionnaires, anthropometry, and laboratory measurements of BMI, waist circumference, insulin resistance, thyroid functionality, and reproductive hormones were used to collect the data. There was also testing of lifestyle factors such as diet, physical activity, smoking, and sleep.


Results: 70 percent obesity, 40 percent insulin-resistance. Imbalances in hormones and sedentary lifestyles were highly fashionable and directly related to infertility.


Conclusion: The reproductive outcome should be improved by metabolic screening, lifestyle and general weight management.


 

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References

1. Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Bio Medica: Atenei Parmensis. 2022 Aug 31;93(4):e2022278.
2. Tang J, Xu Y, Wang Z, Ji X, Qiu Q, Mai Z, Huang J, Ouyang N, Chen H. Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020. BMC Public Health. 2023 Aug 10;23(1):1524.
3. Emokpae MA, Brown SI. Effects of lifestyle factors on fertility: practical recommendations for modification. Reproduction and Fertility. 2021 Jan 8;2(1):R13-26.
4. Zheng L, Yang L, Guo Z, Yao N, Zhang S, Pu P. Obesity and its impact on female reproductive health: unraveling the connections. Frontiers in Endocrinology. 2024 Jan 9;14:1326546.
5. Wang Z, Lai YH, Huang SY, Liu YD, Chen SL. Combined impact of sleep and obesity on female infertility in the NHANES 2017–2020. BMC Women's Health. 2024 Jun 1;24(1):315.
6. Wang Z, Bourgonje AR, Groen H, Abdulle AE, Cantineau AE, van Oers AM, van Dammen L, Bulthuis ML, Wekker V, Mol BW, Roseboom TJ. The effect of lifestyle intervention on systemic oxidative stress in women with obesity and infertility: A post-hoc analysis of a randomized controlled trial. Journal of Clinical Medicine. 2021 Sep 18;10(18):4243.
7. Gonnella F, Konstantinidou F, Donato M, Gatta DM, Peserico A, Barboni B, Stuppia L, Nothnick WB, Gatta V. The molecular link between obesity and the endometrial environment: a starting point for female infertility. International Journal of Molecular Sciences. 2024 Jun 22;25(13):6855.
8. Ke J, Feng Y, Chen Z. Association between waist circumference and female infertility in the United States. PLoS One. 2023 Dec 20;18(12):e0295360.
9. Medenica S, Spoltore ME, Ormazabal P, Marina LV, Sojat AS, Faggiano A, Gnessi L, Mazzilli R, Watanabe M. Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence? Clinical Endocrinology. 2023 Feb;98(2):141-52.
10. Zhu L, Zhou B, Zhu X, Cheng F, Pan Y, Zhou Y, Wu Y, Xu Q. Association between body mass index and female infertility in the United States: data from National Health and Nutrition Examination Survey 2013–2018. International Journal of General Medicine. 2022 Feb 19:1821-31.
11. Liu X, Shi S, Sun J, He Y, Zhang Z, Xing J, Chong T. The influence of male and female overweight/obesity on IVF outcomes: a cohort study based on registration in Western China. Reproductive Health. 2023 Jan 2;20(1):3.
12. Wei W, Zhang X, Zhou B, Ge B, Tian J, Chen J. Effects of female obesity on conception, pregnancy and the health of offspring. Frontiers in Endocrinology. 2022 Aug 11;13:949228.
13. Yin YH, Zhou SY, Lu DF, Chen XP, Liu B, Lu S, Han XD, Wu AH. Higher waist circumference is associated with increased likelihood of female infertility: NHANES 2017-2020 results. Frontiers in Endocrinology. 2023 Oct 20;14:1216413.
14. Wen Z, Li X. Association between weight-adjusted-waist index and female infertility: a population-based study. Frontiers in Endocrinology. 2023 Aug 8;14:1175394.
15. Venkatesh SS, Ferreira T, Benonisdottir S, Rahmioglu N, Becker CM, Granne I, Zondervan KT, Holmes MV, Lindgren CM, Wittemans LB. Obesity and risk of female reproductive conditions: a Mendelian randomisation study. PLoS Medicine. 2022 Feb 1;19(2):e1003679.
16. Deepak Kumar K, Huntriss R, Green E, Bora S, Pettitt C. Development of a nutrition screening tool to identify need for dietetic intervention in female infertility. Journal of Human Nutrition and Dietetics. 2023 Feb;36(1):154-68.
17. Zhang H, Hua L, Liu D, Su X, Chen J, Chen J. Effects of physical activity on infertility in reproductive females. Reproductive Biology and Endocrinology. 2024 May 29;22(1):62.
18. Muhammad T, Wan Y, Lv Y, Li H, Naushad W, Chan WY, Lu G, Chen ZJ, Liu H. Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks. Obesity Reviews. 2023 Oct;24(10):e13603.
19. Pan Q, Shen X, Li H, Zhu B, Chen D, Pan J. Depression score mediate the association between a body shape index and infertility in overweight and obesity females, NHANES 2013–2018. BMC Women's Health. 2023 Sep 2;23(1):471.
20. Al-Ttaie FK, Aljawadi ZA. Hormonal and biochemical study of the effect of obesity on women infertility. Journal of Health and Translational Medicine (JUMMEC). 2021 Mar 18;24(1):53-7.