“FREQUENCY AND OUTCOME OF DYSLIPIDEMIA IN DIABETIC FOOT PATIENTS”
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Abstract
Background: Diabetic foot is a serious complication of diabetes mellitus, contributing to significant morbidity, mortality, and healthcare burden worldwide. Dyslipidemia is frequently observed in diabetic patients and has been implicated in vascular dysfunction and poor ulcer healing. However, limited data exist on its prevalence and impact in diabetic foot patients in Pakistan.
Objective: To identify the prevalence of dyslipidemia and its clinical outcomes among patients with diabetic foot who present to Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan.
Methods: This cross-sectional descriptive study was performed between October, 2024 and April, 2025 at the Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan. One hundred and eighty patients who had diabetic foot ulcers and type 2 diabetes were enrolled. Clinical assessment, ulcer grading, and fasting lipid profiles were conducted. Measures of outcomes evaluated were ulcer healing, surgical intervention, amputation, and in-hospital mortality.
Results: Out of 180 patients, 108 (60%) were male and 72 (40%) were female, with a mean age of 56.8 years ± 9.4 years. There was dyslipidemia in 124 patients (68.9%). Abnormalities that were most widespread included high LDL-C (52.8%), high triglycerides (47.2%), and low HDL-C (42.6%). In dyslipidemic patients, complete healing of the ulcer was observed in 33.1% and 14.5% major amputation and death, respectively. On the contrary, patients without dyslipidemia showed better healing (62.5%), amputation (5.3%), and mortality (5.3%).
Conclusion: Dyslipidemia is extremely common in diabetic foot and is linked to unhealing wounds, higher amputation rates, and mortality. The management and screening of lipids at an early age should be part of the diabetic foot care in Pakistan.
References
2. Vujčić S, Stefanović T, Zeljković A, Mihajlović M, Vekić J. Biomarkers of dyslipidemia in patients with diabetic foot. Arhiv za farmaciju. 2022;72(2):184-92.
3. Ardelean A, Neamtu AA, Balta DF, Neamtu C, Goldis D, Rosu M, et al. Lipid profile paradox: investigating improved lipid levels in diabetic mellitus patients with foot ulcer infections—a prospective descriptive study. Diagnostics. 2023;13(23):3531.
4. Zhang J, Ren T, Han S, Zhao Y. Dyslipidemia and blood indices in the prognosis of diabetic foot ulcers (DFU). [Journal name, year, volume, pages – missing in provided source].
5. Ouyang W, Jia Y, Jin L. Risk factors of diabetic foot ulcer in patients with type 2 diabetes: a retrospective cohort study. Am J Transl Res. 2021;13(8):9554.
6. Bawah AT, Darko R, Abaka-Yawson A, Seini MM, Kinanyok S, Adusei S. Dyslipidemia and its associated factors in patients with type 2 diabetes mellitus. J Public Health. 2021;29(4):985-91.
7. Al Ghadeer HA, Al Barqi M, Almaqhawi A, Alsultan AS, Alghafli JA, AlOmaish MA, et al. Prevalence of dyslipidemia in patients with type 2 diabetes mellitus: a cross-sectional study. Cureus. 2021;13(12).
8. Al Quran TM, Bataineh ZA, Al-Mistarehi AH, Alaabdin AMZ, Allan H, Al Qura’an A, et al. Prevalence and pattern of dyslipidemia and its associated factors among patients with type 2 diabetes mellitus in Jordan: a cross-sectional study. Int J Gen Med. 2022;15:7669.
9. Azhar A, Basheer M, Abdelgawad MS, Roshdi H, Kamel MF. Prevalence of peripheral arterial disease in diabetic foot ulcer patients and its impact in limb salvage. Int J Low Extrem Wounds. 2023;22(3):518-23.
10. Agrawal S, Makuch S, Dróżdż M, Dudzik T, Domański I, Poręba R, et al. The impact of hypoglycemia on patients with diabetes mellitus: a cross-sectional analysis. J Clin Med. 2022;11(3):626.
11. Li J, Nie Z, Ge Z, Shi L, Gao B, Yang Y. Prevalence of dyslipidemia, treatment rate and its control among patients with type 2 diabetes mellitus in Northwest China: a cross-sectional study. Lipids Health Dis. 2022;21(1):77.
12. Al-Rubeaan K, AlMomani M, AlGethami AK, Darandari J, Alsalhi A, AlNaqeeb D, et al. Hearing loss among patients with type 2 diabetes mellitus: a cross-sectional study. Ann Saudi Med. 2021;41(3):171-8.
13. Jaffar MUR, Rafique AD, Khalid SI, Waheed S. Frequency of dyslipidemia in ischemic stroke patients presented to Tertiary Care Hospital of Lahore. Pak J Med Health Sci. 2021;15(10):3417-9.
14. Vural Keskinler M, Feyİzoglu G, Yildiz K, Oguz A. The frequency of malnutrition in patients with type 2 diabetes. Medeniyet Med J. 2021;36(2).
15. Elqadi M, Eweidat K, Abu Sabha M, Yagmour A, Sabarneh A, Nasereddin A, et al. Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients. J Clin Lab Anal. 2021;35(10):e23994.
16. El-Bably MM, Abdallah AM, Metwaly MM, El Mahdi AR, Rashad SM. Frequency and risk factors of abnormal nerve conduction studies in accidentally diagnosed diabetes. Egypt Rheumatol Rehabil. 2023;50(1):25.
17. Zhou R, Li F, Chen G, Fu Q, Gu S, Wu X. Associations between general and abdominal obesity and incident diabetic neuropathy in participants with type 2 diabetes mellitus. J Diabetes. 2021;13(1):33-42.
18. Alshammari NA, Alodhayani AA, Joy SS, Isnani A, Mujammami M, Alfadda AA, et al. Evaluation of risk factors for diabetic peripheral neuropathy among Saudi type 2 diabetic patients with longer duration of diabetes. Diabetes Metab Syndr Obes. 2022;15:3007-14.
19. Madhan S, Rao BSB, Parameshwarappa A, Basavaraj BM, Ganesh PB, Shetty S, et al. Evaluation of the effects of dyslipidemia on hearing in patients with type 2 diabetes mellitus. Indian J Otolaryngol Head Neck Surg. 2023;75(Suppl 1):541-7.
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Muhammad Adnan Sarwar
Senior Registrar, Department of Medicine, Faisalabad Teaching Hospital, Faisalabad, Pakistan
Muhammad Moiez
Demonstrator ENT, Department of ENT, Aziz Fatimah Hospital Faisalabad, Pakistan
Hamza Nasir
House Officer, Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan
Anas Mustafa
House Officer, Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan
Muhammad Saqib
Postgraduate Resident, Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan
Qudsia Babar
House Officer, Department of Medicine, Aziz Fatima Hospital, Faisalabad, Pakistan