ANATOMICAL AND PATHOPHYSIOLOGICAL FEATURES OF VARICOSE VEINS: USING DUPLEX ULTRASOUND
Main Article Content
Keywords
Abstract
Varicose veins are a common manifestation of chronic venous insufficiency, often associated with incompetence at key venous junctions and perforator veins. Duplex ultrasonography is the diagnostic modality of choice for evaluating both the anatomical and functional aspects of venous abnormalities. This study aimed to assess the anatomical patterns and distribution of saphenous and perforator incompetence among patients with varicose veins using duplex ultrasound. Methods: A six-month prospective study was conducted in the Departments of Anatomy and Radiodiagnosis, Government Medical College, Srinagar. Of 400 patients presenting with lower limb venous symptoms, 262 (65.5%) diagnosed with varicose veins were included for detailed assessment. Duplex ultrasonography (Philips Affiniti 50/70) with Valsalva and distal compression maneuvers was used to evaluate junctional and perforator incompetence. Data were analyzed using SPSS v20.0, with p-values <0.05 considered statistically significant. Results: Out of 262 patients with varicose vein, 168 (64.1%) demonstrated junction incompetence. Of these, 106 (63.1%) had saphenofemoral junction (SFJ) incompetence, 14 (8.3%) had saphenopopliteal junction (SPJ) incompetence, and 48 (28.6%) had incompetence at both SFJ and SPJ. Perforator incompetence was noted in 213 patients (81.3%), while 49 (18.7%) had competent perforators. The most commonly affected site was the medial mid-third below the knee (70.9%), followed by the medial lower third below the knee (64.3%). Incompetence in the calf (6.1%) and ankle (4.2%) was less frequent. Conclusion: A high prevalence of junctional and perforator incompetence was observed in varicose vein patients, emphasizing the critical role of duplex ultrasonography in diagnosis and treatment planning.
References
2. Evans CJ, Fowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health. 1999;53:149–153.
3. Kumar VN, Chitra V, Tamilanban T. Molecular and genetic insights into varicose veins. Gene Reports. 2025 May 19:102260.
4. Bradbury AW. Pathophysiology and Principles of Management of Varicose Veins. In: Fitridge R, Thompson M, editors. Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists [Internet]. Adelaide (AU): University of Adelaide Press; 2011. 24. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534256/
5. Takase S, Pascarella L, Lerond L, Bergan JJ, Schmid-Schönbein GW. Venous hypertension, inflammation and valve remodeling. European Journal of Vascular and Endovascular Surgery. 2004 Nov 1;28(5):484-93.
6. Irodi A, Keshava SN, Agarwal S, Korah IP, Sadhu D. Ultrasound Doppler evaluation of the pattern of involvement of varicose veins in Indian patients. Indian J Surg. 2011 Apr;73(2):125-30. doi: 10.1007/s12262-010-0195-0. Epub 2010 Dec 14. PMID: 22468062; PMCID: PMC3077159.
7. Rutherford EE, Kianifard B, Cook SJ, Holdstock JM, Whiteley MS. Incompetent perforating veins are associated with recurrent varicose veins. Eur J Vasc Endovasc Surg. 2001 May;21(5):458-60. doi: 10.1053/ejvs.2001.1347. PMID: 11352523.
8. Krishnan S, Nicholls SC. Chronic venous insufficiency: clinical assessment and patient selection. Semin Intervent Radiol. 2005 Sep;22(3):169-77. doi: 10.1055/s-2005-921961. PMID: 21326690; PMCID: PMC3036279.
9. Clark A, Harvey I, Fowkes FGR. Epidemiology and risk factors for varicose veins among older people: cross-sectional population study in the UK. Phlebology. 2010;25(5):236-240. doi:10.1258/phleb.2009.009045
10. Brand FN, Dannenberg AL, Abbott RD, Kannel WB. The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988 Mar-Apr;4(2):96-101. PMID: 3395496.
11. Tisi PV. Varicose veins. BMJ Clin Evid. 2011 Jan 5;2011:0212. PMID: 21477400; PMCID: PMC3217733.
12. Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. The epidemiology of chronic venous insufficiency and varicose veins. Annals of epidemiology. 2005 Mar 1;15(3):175-84.
13. Bashir J, Das K, Ahuja P, Arain MS. Clinical features and risk factors of varicose veins at Liaquat University Hospital Hyderabad. Pak J Surg. 2013;29(2):127-30
14. Sharma D, Souza J, Joshi P.Role of colour Doppler in evaluation of venous abnormalities of lower limb.IntSurg J2020;7:163-7.
15. Arumugam S, Manaswini DP, Reddy PA, Ghoshal JA, Subbiah NK. A Study of ValvularIncompetencies in the Lower Limb Veins Using Doppler Ultrasound Findings. Cureus. 2024 Feb 7;16(2):e53765. doi: 10.7759/cureus.53765. PMID: 38465064; PMCID: PMC10922251.
16. Azhar MA. Role of Colour flow duplex sonographyin evaluation of chronic venous insufficiency in lower limbs. Radiology. 2017;2(3):80-4
17. Delis KT, Ibegbuna V, Nicolaides AN, Lauro A, Hafez H. Prevalence and distribution of incompetent perforating veins in chronic venous insufficiency. Journal of vascular surgery. 1998 Nov 1;28(5):815-25.
18. Townsend J, Jones H, Williams JE. Detection of incompetent perforating veins by venography at operation. British Medical Journal. 1967 Sep 9;3(5565):583.
19. Pierik EG, Toonder IM, van Urk H, Wittens CH. Validation of duplex ultrasonography in detecting competent and incompetent perforating veins in patients with venous ulceration of the lower leg. Journal of vascular surgery. 1997 Jul 1;26(1):49-52.