LIPID PROFILE AND HISTOPATHOLOGICAL CHANGES IN PLACENTAE OF WOMEN WITH PREECLAMPSIA
Main Article Content
Keywords
Preeclampsia, Lipid Profile, Placental Histopathology, Triglycerides, Syncytial Knotting, Decidual Vasculopathy, Pregnancy Complications
Abstract
Background
To assess and compare the lipid profiles and histopathological placental changes in women with preeclampsia and normotensive pregnancies.
Methods
This cross-sectional study was conducted at Jinnah Medical College, Peshawar, from January 2022 to January 2023. A total of 71 pregnant women were enrolled 36 diagnosed with preeclampsia and 35 normotensive controls. Blood samples were taken for lipid profile analysis, including total cholesterol, triglycerides, HDL, LDL, and VLDL. Placentae collected after delivery were examined histologically for infarction, fibrinoid necrosis, syncytial knotting, thrombotic lesions, and other changes. Statistical comparisons were made using SPSS, with significance set at p<0.05.
Results
‘Women with preeclampsia had significantly elevated levels of total cholesterol, triglycerides, LDL, and VLDL, along with reduced HDL (p<0.001)’. Placental histology showed higher incidences of infarction (66.7%), fibrinoid necrosis (58.3%), thrombotic lesions (52.8%), and decidual vasculopathy (47.2%) in preeclamptic women, all statistically significant (p<0.001).
Conclusion
Preeclampsia is associated with a distinct atherogenic lipid profile and substantial histopathological damage to the placenta. Routine lipid monitoring during antenatal care and pathological assessment of placentae in hypertensive pregnancies can aid in early detection and management strategies.
References
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Sadia Nasir
Assistant Professor, Department of Obstetrics and Gynaecology, Khyber Teaching Hospital, Peshawar, Pakistan
Dr Sumbul Aqeeq
Senior Lecturer, Department of Biochemistry, Kabir Medical College, Peshawar, Pakistan
Dr Shabana Bano Soomro
Assistant Professor, OBGYN Unit 3, Shaheed Muhtarma Benazir Bhutto Medical University, Chandka Medical College, Shaikh Zayed Women Hospital, Larkana, Pakistan
Dr Muhammad Razaq
Assistant Professor, Department of Biochemistry, Jinnah Medical College, Peshawar, Pakistan
Dr Farhan Abbas Baloch
Associate Professor, Department of Pathology, Pak International Medical College, Peshawar, Pakistan
Dr Tania Khattak
Assistant Professor, Department of Histopathology, Nowshera Medical College, Nowshera, Pakistan