MATERNAL SERUM URIC ACID AND CREATININE LEVEL IN NORMAL PREGNANT AND PRE- ECLAMPTIC WOMEN: AN OBSERVATIONAL STUDY.
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Keywords
Pre-eclampsia, Serum creatinine, Uric acid
Abstract
Pre-eclampsia is a disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Serum creatinine and uric acid has been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. This study compares the serum creatinine and uric acid in pre -eclampsia case and normal pregnant women and to assess its role in pre-eclampsia.
Method:50 Patients diagnosed as having Pre-eclampsia and 50 controls with similar age group were studied at Biochemistry department, RIMS Ranchi.serum uric acid was analyzed by using principle of uricase peroxidase method and serum creatinine was analyzed by using principle of Jaffe method.
Results: The mean serum concentrations of uric acid in preeclamptic pregnant women was significantly higher when compared to normal pregnant women , p< 0.05. There was no statistically significant difference for serum creatinine level in preeclamptics compared to normotensive pregnant women(p > 0.05).
Conclusion: serum uric acid level increased in pre-eclamptic women and there was no significant difference in the Serum creatinine level in preeclampsia patients and healthy pregnant women.
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Dr Mahto Hemanti Raghu
Senior Resident, Department of Biochemistry, Sahid Nirmal Mahto Medical College, Dhanbad
Dr Avnish Kumar Tarwey
Senior Resident, Department of Biochemistry, Medinirai Medical College, Palamu,
Dr Renu Yadav
Senior Resident, Department of Gynaecology, Laxmichandravanshi Medical College, Palamu
Dr Mridula Bharti
Senior Resident, Department of Biochemistry, Phulo Jhano Medical College, Dumka,
Dr Rajiv Kumar Mahli
Associate Professor, Department of Biochemistry, Sheikh Bhikari Medical College, Hazaribagh