CORRELATION BETWEEN HISTOPATHOLOGICAL FINDINGS AND CLINICAL OUTCOMES IN CHRONIC RHINOSINUSITIS
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Keywords
Interleukin-33, periostin, chronic rhinosinusitis, nasal polyps, eosinophilic infiltration, and biomarkers.
Abstract
Introduction: Chronic rhinosinusitis, a particular kind of chronic inflammation of the sinuses, causes facial pain and nasal congestion. The disease's onset is influenced by immunopathological processes and inflammation involving eosinophils, as well as genetic and environmental factors.
Objective: The purpose of this study is to delineate the relationship of current histological characteristics of CRS with patient outcomes and investigate the role of eosinophils, goblet cells in the mucus layer, and inflammatory cytokines such as periostin and interleukin 33 (IL 33).
Materials and Method: A cross-sectional study was conducted on 100 CRS patients at Niazi Medical College Sargodha, Pakistan. A histological evaluation of tissue samples was later collected following the clinical assessment. The levels of biomarkers were analyzed using immunohistochemical techniques.
Results: Positive correlations between the density of goblet cells, the thickness of the mucus layer, the count of eosinophils, and signs of nasal obstruction (positive Sneezing Perception Test), facial pain (positive Brief Facial Pain Inventory), and anosmia (positive Sniffin’Sticks) were found. In addition, a higher level of periostin and IL 33 was related to more severe CRS.
References
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Sabah Kaleem Baloch
Assistant Professor, Department of of Pathology, Niazi Medical College Sargodha, Pakistan
Maqbool Ahmed Baloch
Associate Professor, Department of ENT, Niazi Medical College Sargodha, Pakistan