ROLE OF GENE ENCODING DNA BINDING PROTEIN IN RELATION TO NUCLEAR MATRIX ATTACHMENT REGION IN ORAL SQUAMOUS CELL CELL CARCINOMA - A SYSTEMATIC REVIEW
Main Article Content
Keywords
oral, maxillofacial, oncology, carcinoma, squamous cell
Abstract
Introduction
Oral squamous cell carcinoma (OSCC) is a significant global health concern, representing over 90% of all oral malignancies. Its aggressive nature and propensity for local invasion, nodal metastasis, and recurrence contribute to a poor prognosis, with a 5-year survival rate remaining at approximately 50%. This review aims to systematically evaluate the current literature on SATB2 expression in OSCC, focusing on its correlation with clinicopathological features such as tumor size, nodal involvement, and metastatic potential.
Methods
A comprehensive search was conducted using databases including PubMed, Scopus, Web of Science, and Embase. Keywords used were "SATB2," "oral squamous cell carcinoma," "OSCC," "biomarker," and "prognosis."
Results
SATB2 serves as a prognostic biomarker, aiding in predicting the clinical outcome and progression of OSCC.
Discussion and Conclusion
This systematic review underscores the pivotal role of SATB2 in the progression and prognosis of various squamous cell carcinomas (SCCs), including oral squamous cell carcinoma (OSCC), spindle cell squamous cell carcinoma (SpSCC), sarcomatoid squamous cell carcinoma (sSCC), and laryngeal squamous cell carcinoma (LSCC).
References
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr.N.Inbanesan
Senior Lecturer in Department of OMFS. Karpaga vinayaga Institute of Dental sciences,Mathuranthagam, Tamilnadu, India,
