CLINICAL PROFILE OF POLYCYSTIC OVARY SYNDROME AND ITS METABOLIC CORRELATES IN YOUNG WOMEN: A CROSS‑SECTIONAL STUDY.
Main Article Content
Keywords
Polycystic ovary syndrome, Rotterdam criteria, insulin resistance, metabolic syndrome, South Asian women.
Abstract
Polycystic ovary syndrome (PCOS) occurs in 5-18 percent of women of reproductive age worldwide, and the prevalence is increased in South Asia by genetic susceptibility and insulin resistance. This paper characterized clinical presentation and metabolic equivalents with Rotterdam criteria of young Indian women to guide risk stratification at an early age.
Methods: Cross-sectional study of 200 non-pregnant women aged 18-30 years who came to a tertiary care hospital (January-December 2022). After the elimination of mimics PCOS Diagnosis was [?]2 Rotterdam criteria. The measurements were anthropometry, Ferriman-Gallwey scoring, transabdominal ultrasound, fasting glucose/insulin (HOMA-IR), lipids, and metabolic syndrome as per the IDF South Asian criteria.
Findings: The prevalence of PCOS was 28% (56/200) and phenotype A was preponderant (39.3%). There was 67.9% vs 28.5% insulin resistance(HOMA-IR>2.5) between PCOS vs controls, 35.7% vs 12.5% in metabolic syndrome (p<0.001). Waist circumference (OR 3.2) and fasting insulin (OR 4.1) were the best predictors.
Conclusion: PCOS is a high burden with a phenotype characterized by metabolic gradients that requires regular anthropometric/HOMA-IR screening and lifestyle changes to reduce cardiometabolic development among young Indian female.
References
2. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19-25.[3]
3. Azziz R, Carmina E, Dewailly D, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab. 2009;91(11):4237-45.[6]
4. Bremer AA. Insulin resistance in polycystic ovarian syndrome. Indian J Endocrinol Metab. 2022;26(10):966-75.[4]
5. Kumar RM, et al. Prevalence of metabolic syndrome in women with polycystic ovary syndrome and the factors associated: A cross sectional study at a tertiary care center in Hyderabad, south-eastern India. Diabetes Metab Syndr. 2020;14(6):1695-1700.[5]
6. Joshi T, et al. A cross-sectional study of polycystic ovarian syndrome in adolescent and young girls in Mumbai, India. J Obstet Gynecol India. 2010;60(2):156-62.[3]
7. Nidhi R, et al. Prevalence of polycystic ovarian syndrome in Indian adolescents. J Pediatr Adolesc Gynecol. 2011;24(4):223-7.[3]
8. Wijeyaratne CN, et al. Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic. Hum Reprod. 2011;26(1):202-10.[4][5]
9. Singh S, et al. Polycystic ovarian syndrome and insulin resistance: a North Indian study. Int J Res Med Sci. 2017;5(3):1024-8.[6]
10. Norman RJ, et al. Metabolic risk assessment of Indian women with polycystic ovarian syndrome. Gynecol Endocrinol. 2018;34(9):745-50.[7]
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Kavita Devi
P.G. Resident, Department of Obstetrics & Gynecology, Shyam Shah Medical College, Rewa (M.P.)
Dr. Khushboo Soni
Senior Resident, Department of Obstetrics & Gynecology, Shyam Shah Medical College, Rewa (M.P.)
