ASSESSING THE CO-OCCURRENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE AND METABOLIC SYNDROME IN JAMMU AND KASHMIR: A CORRELATIONAL STUDY
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Keywords
Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome, Jammu and Kashmir, Correlational Study
Abstract
Background: The relationship between NAFLD and MetS has been well-documented in scientific literature. NAFLD is often considered the hepatic manifestation of MetS due to shared risk factors, including insulin resistance, obesity, and dyslipidemia. The coexistence of these conditions increases the risk of cardiovascular morbidity and mortality. Methodology: Group I consisted of 140 healthy control subjects, By routine examination, it was ensured that all subjects were healthy while Group II consisted of 140 patients with non-alcoholic fatty liver disease (NAFLD). Metabolic syndrome was diagnosed as per NCEP ATP III criteria. A 2 ml and 5 ml fasting venous blood sample was collected in sodium fluoride and gel separator tube under sterile conditions. The supernatant was collected, and biochemical estimations was carried out for all study participants. Results: Around 46.4% of study subjects were having grade I Fatty liver while 34.2% and rest 19.2% had grade II and grade III Fatty liver respectively. Waist circumference, BMI, liver enzymes (AST, ALT), blood glucose, serum triglycerides, HDL levels, and blood pressure (systolic and diastolic) all increased progressively from the Healthy control group to the Fatty liver and Fatty liver + MS groups, with p-values <0.05 indicating statistical significance. Conclusion: There is significant co-occurrence of Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome in the study population. The findings underscore the importance of early screening, lifestyle modifications, and increased public awareness to address the rising burden of these conditions.
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Aneesa Fatima
PhD scholar, Department of Biochemistry, National Institute of Medical Sciences and Research, NIMS University, Jaipur, Rajasthan
Sandeep Tripathi
Professor, Department of Biochemistry, National Institute of Medical Sciences and Research, NIMS University, Jaipur, Rajasthan
Jamil-Ul-Hussain
Associate Professor, Department of General Medicine, Govt. Medical College, Rajouri J&K