AN ANALYTICAL RESEARCH COMPARING PERIPHERAL VENOUS BLOOD CULTURE AND UMBILICAL CORD BLOOD CULTURE FOR THE DIAGNOSIS OF EARLY-ONSET NEONATAL SEPSIS
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Keywords
Sepsis, Early detection of neonatal sepsis, Streptococcus anginosus
Abstract
Early detection of neonatal sepsis has proven challenging in developing nations. The limited sensitivity of some blood biomarkers, such as fibrinogen, haptoglobin, and C-reactive protein (CRP), that can be used as broad indications of bacterial sepsis has raised doubts about their usefulness. Therefore, the purpose of the current study was to compare the assessment of AEONS by UCB and PBC. For our prospective investigation, a total of 88 newborn neonates were selected. We collected clinical data and conducted routine laboratory testing. For both aerobic and anaerobic blood cultures, we used 1 ml aseptically obtained blood samples. Using MedCalc's online statistical calculator, we assessed PCB and UBC's diagnostic test sensitivity and specificity. Intrapartum antibiotic exposure occurred in 12.5% of instances of clinical sepsis, and placental chorioamnionitis symptoms were observed in 15.27% of cases. Placental chorioamnionitis was confirmed in just one of the two individuals with a single organism UCBC (Streptococcus anginosus). When detecting neonatal sepsis in high-risk neonates, UCBC outperforms venous culture in terms of sensitivity and specificity.
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Dubey Shailesh Kumar
Assistant Professor Department of Paediatrics, Varun Arjun Medical College and Rohilkhand Hospital, Banthra Distt. Shajahanpur U.P. Pin code 242307.