‘’ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) ‘’
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Keywords
Acute respiratory distress syndrome, causes, pathophysiolog
Abstract
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of diffuse lung inflammation and oedema that commonly causes acute respiratory failure. ARDS was identified in 10·4% of intensive care unit admissions in 2016.1 Global awareness of ARDS has been heightened during the COVID-19 pandemic due to a sharp increase in the incidence of ARDS. This Series paper describes the current understanding of the pathophysiology of ARDS and summarises new developments in the identification of more homogeneous phenotypes within this highly heterogeneous clinical syndrome. The diagnosis and treatment of ARDS is reviewed in another paper in this Series.
References
1. Bellani, G ∙ Laffey, JG ∙ Pham, T ∙ et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries
2. Simou, E ∙ Leonardi-Bee, J ∙ Britton, J, The effect of alcohol consumption on the risk of ARDS: a systematic review and meta-analysis
3. Calfee, CS ∙ Matthay, MA ∙ Kangelaris, KN ∙ et al. Cigarette smoke exposure and the acute respiratory distress syndrome
4. Moazed, F ∙ Hendrickson, C ∙ Jauregui, A ∙ et al.
5. Cigarette smoke exposure and ARDS in sepsis: epidemiology, clinical features, and biologic markers
6. Reilly, JP ∙ Zhao, Z ∙ Shashaty, MGS ∙ et al. Low to moderate air pollutant exposure and acute respiratory distress syndrome after severe trauma
7. Ware, LB ∙ Zhao, Z ∙ Koyama, T ∙ et al. Long-term ozone exposure increases the risk of developing the acute respiratory distress syndrome
8. Toy, P ∙ Looney, MR ∙ Popovsky, M ∙ et al. Transfusion-related acute lung injury: 36 years of progress (1985-2021)
9. Gong, MN ∙ Thompson, BT ∙ Williams, P ∙ et al. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion
10. Reilly, JP ∙ Christie, JD ∙ Meyer, NJ Fifty years of research in ARDS genomic contributions and opportunities
11. Kerchberger, VE ∙ Bastarache, JA ∙ Shaver, CM ∙ et al. Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis
12. Sommerfeld, CG ∙ Weiner, DJ ∙ Nowalk, A ∙ et al. Hypersensitivity pneumonitis and acute respiratory distress syndrome from e-cigarette use
13. Moritz, ED ∙ Zapata, LB ∙ Lekiachvili, A ∙ et al. Update: characteristics of patients in a national outbreak of e-cigarette, or vaping, product use-associated lung injuries - United States, October 2019
14. Matsumoto, S ∙ Fang, X ∙ Traber, MG ∙ et al. Dose-dependent pulmonary toxicity of aerosolized vitamin E acetate
15. Reuss, JE ∙ Suresh, K ∙ Naidoo, J, Checkpoint inhibitor pneumonitis: mechanisms, characteristics, management strategies, and beyond
16. Ashbaugh, DG ∙ Bigelow, DB ∙ Petty, TL ∙ et al. Acute respiratory distress in adults
17. Martin, TR ∙ Zemans, RL ∙ Ware, LB ∙ et al. New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome
18. Matthay, MA ∙ Zemans, RL ∙ Zimmerman, GA ∙ et al. Acute respiratory distress syndrome
19. Thille, AW ∙ Peñuelas, O ∙ Lorente, JA ∙ et al. Predictors of diffuse alveolar damage in patients with acute respiratory distress syndrome: a retrospective analysis of clinical autopsies
20. Thille, AW ∙ Esteban, A ∙ Fernández-Segoviano, P ∙ et al. Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy
21. Bachofen, M ∙ Weibel, ER, Structural alterations of lung parenchyma in the adult respiratory distress syndrome
22. Guerin, C ∙ Bayle, F ∙ Leray, V ∙ et al. Open lung biopsy in nonresolving ARDS frequently identifies diffuse alveolar damage regardless of the severity stage and may have implications for patient management
23. Ware, LB ∙ Matthay, MA Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
24. Matthay, MA ∙ Folkesson, HG ∙ Clerici, C, Lung epithelial fluid transport and the resolution of pulmonary edema
25. Ikegami, M ∙ Falcone, A ∙ Whitsett, JA STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury
26. Zuo, YY ∙ Veldhuizen, RAW ∙ Neumann, AW ∙ et al. Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation
27. Tolle, LB ∙ Standiford, TJ Danger-associated molecular patterns (DAMPs) in acute lung injury
28. Rizzo, AN ∙ Haeger, SM ∙ Oshima, K ∙ et al. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome
29. Bastarache, JA ∙ Wang, L ∙ Wang, Z ∙ et al. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
30. Wang, L ∙ Bastarache, JA ∙ Wickersham, N ∙ et al. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.
2. Simou, E ∙ Leonardi-Bee, J ∙ Britton, J, The effect of alcohol consumption on the risk of ARDS: a systematic review and meta-analysis
3. Calfee, CS ∙ Matthay, MA ∙ Kangelaris, KN ∙ et al. Cigarette smoke exposure and the acute respiratory distress syndrome
4. Moazed, F ∙ Hendrickson, C ∙ Jauregui, A ∙ et al.
5. Cigarette smoke exposure and ARDS in sepsis: epidemiology, clinical features, and biologic markers
6. Reilly, JP ∙ Zhao, Z ∙ Shashaty, MGS ∙ et al. Low to moderate air pollutant exposure and acute respiratory distress syndrome after severe trauma
7. Ware, LB ∙ Zhao, Z ∙ Koyama, T ∙ et al. Long-term ozone exposure increases the risk of developing the acute respiratory distress syndrome
8. Toy, P ∙ Looney, MR ∙ Popovsky, M ∙ et al. Transfusion-related acute lung injury: 36 years of progress (1985-2021)
9. Gong, MN ∙ Thompson, BT ∙ Williams, P ∙ et al. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion
10. Reilly, JP ∙ Christie, JD ∙ Meyer, NJ Fifty years of research in ARDS genomic contributions and opportunities
11. Kerchberger, VE ∙ Bastarache, JA ∙ Shaver, CM ∙ et al. Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis
12. Sommerfeld, CG ∙ Weiner, DJ ∙ Nowalk, A ∙ et al. Hypersensitivity pneumonitis and acute respiratory distress syndrome from e-cigarette use
13. Moritz, ED ∙ Zapata, LB ∙ Lekiachvili, A ∙ et al. Update: characteristics of patients in a national outbreak of e-cigarette, or vaping, product use-associated lung injuries - United States, October 2019
14. Matsumoto, S ∙ Fang, X ∙ Traber, MG ∙ et al. Dose-dependent pulmonary toxicity of aerosolized vitamin E acetate
15. Reuss, JE ∙ Suresh, K ∙ Naidoo, J, Checkpoint inhibitor pneumonitis: mechanisms, characteristics, management strategies, and beyond
16. Ashbaugh, DG ∙ Bigelow, DB ∙ Petty, TL ∙ et al. Acute respiratory distress in adults
17. Martin, TR ∙ Zemans, RL ∙ Ware, LB ∙ et al. New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome
18. Matthay, MA ∙ Zemans, RL ∙ Zimmerman, GA ∙ et al. Acute respiratory distress syndrome
19. Thille, AW ∙ Peñuelas, O ∙ Lorente, JA ∙ et al. Predictors of diffuse alveolar damage in patients with acute respiratory distress syndrome: a retrospective analysis of clinical autopsies
20. Thille, AW ∙ Esteban, A ∙ Fernández-Segoviano, P ∙ et al. Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy
21. Bachofen, M ∙ Weibel, ER, Structural alterations of lung parenchyma in the adult respiratory distress syndrome
22. Guerin, C ∙ Bayle, F ∙ Leray, V ∙ et al. Open lung biopsy in nonresolving ARDS frequently identifies diffuse alveolar damage regardless of the severity stage and may have implications for patient management
23. Ware, LB ∙ Matthay, MA Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome
24. Matthay, MA ∙ Folkesson, HG ∙ Clerici, C, Lung epithelial fluid transport and the resolution of pulmonary edema
25. Ikegami, M ∙ Falcone, A ∙ Whitsett, JA STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury
26. Zuo, YY ∙ Veldhuizen, RAW ∙ Neumann, AW ∙ et al. Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation
27. Tolle, LB ∙ Standiford, TJ Danger-associated molecular patterns (DAMPs) in acute lung injury
28. Rizzo, AN ∙ Haeger, SM ∙ Oshima, K ∙ et al. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome
29. Bastarache, JA ∙ Wang, L ∙ Wang, Z ∙ et al. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
30. Wang, L ∙ Bastarache, JA ∙ Wickersham, N ∙ et al. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.
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Published
Jan 15, 2017
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How to Cite
Dr. Narayan P. Survase, & Dr. Ravindra R. Salve. (2017). ‘’ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) ‘’. Journal of Population Therapeutics and Clinical Pharmacology, 24(1), 93-105. https://doi.org/10.53555/mg5pf628
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Author Biographies
Dr. Narayan P. Survase
[M.B.B.S, M.D (Medicine), G.M.C, Nagpur
Dr. Ravindra R. Salve
[M. B.B. S, D. T.C.D.] B. J. Medical College, Pune
How to Cite
Dr. Narayan P. Survase, & Dr. Ravindra R. Salve. (2017). ‘’ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) ‘’. Journal of Population Therapeutics and Clinical Pharmacology, 24(1), 93-105. https://doi.org/10.53555/mg5pf628