STUDY OF CARBAPENEM RESISTANCE IN E. COLI ISOLATES
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Keywords
carbapenamse, imipenem resistance , amikacin
Abstract
Background: Enterobacteriaceae, such as Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii and Enterobacter cloacae, are the most common pathogenic bacteria for nosocomial infection. Enterobacteriaceae accounted for 60–70% of all Gram-negative bacteria. Among them E. coli are very common bacteria in the gastrointestinal tract, and part of the normal bacterial flora in humans but are also a common cause of severe infections. It is one of the major etiologic agents for urinary tract infection, sepsis, and meningitis. The carbapenems (imipenem, meropenem, and ertapenem) are sometimes the only effective agents for treatment of severe infection.
Materials and Methods: This prospective compareative study was carried from OPD out Patient of Department of Microbiology at Muzaffarnagar Medical College,Muzaffareanagar UP. Study design is Hospital based observational study and Study place was in Department of Microbiology, Muzaffarnagar Medical College And Hospital. Study population would include samples of enterobacteriacae collected in patients OPD
Study duration around 15 days and Study size was 30 samples Sampling technique are Purposive sampling Inclusion Criterion carried of Patients having Carbapenem Resistance in E.coli isolates and Exclusion Criterion are Patients having other antimicrobial resistance in E.coli Isolates such as:Ampicillin ,Tetracycline, Cefotaxime resistance
Results: Out of 30 E. coli (Gram-negative bacteria) isolated from diferent clinical samples, 17 (16.8%) were carbapenemase producers. The isolates found were from diferent age group patients ranging from 8 to 80 years old. Isolates from males 63.3% (19/30) were more in number as compared to isolate from female 36.6% (11/30). Carbapenemase-producing isolates were found in the following clinical specimens: Urine: 66.6%,High vaginal swab: 57.1%,Pus: 40%,Sputum: 50%,Blood: 0%. Urine samples had the highest number of carbapenem-resistant isolates
Conclusion: The emergence and spread of carbapenem-resistant bacteria are a global health issue. Even though carbapenems are used in human medicine, several studies showed that carbapenem-resistant bacteria are found in humans, food-producing animals, foods, water sources, etc., due to the rapid dissemination in the complex web, affecting the health of people
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Mr Ravi Vashistha
Ph.D Scholar Department of Microbiology NIMS University Jaipur, Rajasthan
Dr Siva Prasad Reddy B
Professor Department of Microbiology NIMS University Jaipur, Rajasthan
Dr Sapna Chauhan
Professor and HOD Department of Microbiology, Muzaffarnagar Medical College, Muzaffarnagar.