EXPLORING THE THERAPEUTIC POTENTIAL OF CURCUMA LONGA RHIZOME EXTRACT TO MITIGATE DYSLIPIDEMIA
Main Article Content
Keywords
CURCUMA, RHIZOME , DYSLIPIDEMIA, longa
Abstract
Various researches have publicized that different parts of Curcuma longa plant possess therapeutic potential to tackle dyslipidemia and associated inflammatory issues which is one of the key contributory factors leading to the oxidative stress, cardiovascular diseases and other associated metabolic problems. The current study was done to explore the ability of Curcuma longa rhizome extract to regulate lipids in rabbits with induced dyslipidemia. The Soxhlet method was used to create the ethanolic extract of Curcuma longa rhizome. The obtained extract was applied on experimental rabbits in this trial. For this purpose, 25 healthy rabbits were arranged to accomplish the trial. These rabbits were then divided into five groups, with five rabbits in each group; the healthy rabbits were fed a regular diet, while the NC (Negative Control) rabbits were given a normal diet. The remaining 20 rabbits were given a high-fat diet on a regular basis for 28 days, and then they received a dose-dependent ethanolic extract of Curcuma longa rhizome on a regular basis for two months. This caused dyslipidemia in the rabbits. Rabbits in the PC (Positive Control) group had dyslipidemia and were fed a normal diet, whereas the G1, G2, and G3 groups also had dyslipidemia but were given varying dosages of Curcuma longa rhizome extract (50, 100, and 150 mg per kilogram of body weight, respectively). Every 15 days, blood samples were taken and analyzed to determine the serum lipid profile in order to assess the effectiveness of the prescribed medication. A significant reduction in low-density lipoprotein (49.01±2.1mg/dL), total cholesterol (80.18± 3.4mg/dL) and triglycerides (49.01±2.1mg/dL) was seen in G2 (P<0.05), on the other hand there was a significant improvement in the high-density lipoprotein level (40.39±1.7mg/dL) of G2 in comparison to that of other groups. Findings of this study suggest that giving the ethanolic extract of Curcuma longa rhizome (at 100 mg/kg) orally to G2 on a regular basis for 60 days reduced the lipid profile of dyslipidemic rabbits by significantly lowering their low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG) levels and raising their high-density lipoprotein (HDL) levels.
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Umar Rehman
National Institute of Food Science and Technology, University of Agriculture, Faisalabad, 38000, Pakistan
Qamar Abbas Syed
National Institute of Food Science and Technology, University of Agriculture, Faisalabad, 38000, Pakistan
Rizwan Shukat
National Institute of Food Science and Technology, University of Agriculture, Faisalabad, 38000, Pakistan
Beenish Israr
Institute of Home Sciences, University of Agriculture, Faisalabad 38000, Pakistan