THE IMPACT OF A GLUTEN-FREE DIET ON THYROID AUTOIMMUNITY IN DRUG-NAÏVE WOMEN WITH HASHIMOTO'S THYROIDITIS
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Abstract
The aim of this research was to explore if a gluten-free diet influences thyroid autoimmunity, the functioning of the hypothalamic-pituitary-thyroid axis, and the outcomes of thyroid function tests among women diagnosed with Hashimoto’s thyroiditis who also showed positive results for anti-tissue transglutaminase antibodies. The study involved 68 women with autoimmune thyroiditis, divided into two distinct groups. The first group (group A, n = 32) adhered to a gluten-free diet for a duration of 6 months, whereas the other group (group B, n = 36) did not receive any dietary intervention. Measurements of serum levels for thyroid peroxidase and thyroglobulin antibodies, along with thyrotropin, free thyroid hormones, and 25-hydroxyvitamin D, were taken at both the start of the study and again after 6 months. Using the levels of thyrotropin and free thyroid hormones, Jostel’s thyrotropin index, SPINA-GT index, and SPINA-GD index were computed. All participants finished the study as intended. In group B, levels of serum thyrotropin and free thyroid hormones, along with 25-hydroxyvitamin D levels and the derived indices, did not show any significant changes. The gluten-free diet led to a decrease in thyroid antibody levels and a slight elevation in 25-hydroxyvitamin D levels and the SPINA-GT index. In group A, the effect on TPOAb and TgAb levels was associated with the modifications in the SPINA-GT index, while the changes in TPOAb correlated with variations in 25-hydroxyvitamin D levels. The findings imply that a gluten-free diet could offer clinical advantages for women suffering from autoimmune thyroid disorders.
References
2. Caturegli P, Kimura H, Rocchi R et al. Autoimmune thyroid diseases. Curr Opin Rheumatol 2007; 19: 44–48
3. Brown RS. Autoimmune thyroid disease: Unlocking a complex puzzle. Curr Opin Pediatr 2009; 21: 523–528
4. Hadithi M, de Boer H, Meijer JW et al Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa. World J Gastroenterol 2007; 13: 1715–1722
5. Stazi AV, Trinti B. Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid disease. Ann Ist Super Sanita 2010; 46: 389–399
6. Fisher AH, Lomasky SJ, Fisher MJ et al. Celiac disease and the endocrinologist: A diagnostic opportunity. Endocr Pract 2008; 14: 381–388
7. Naiyer AJ, Shah J, Hernandez L et al. Tissue transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid dysfunction. Thyroid 2008; 36: 1171–1178
8. Krysiak R, Okopień B. The effect of levothyroxine and selenomethio- nine on lymphocyte and monocyte cytokine release in women with Hashimoto’s thyroiditis. J Clin Endocrinol Metab 2011; 96: 2206–2215
9. Jostel A, Ryder WD, Shalet SM. The use of thyroid function tests in the diagnosis of hypopituitarism: Definition and evaluation of the TSH index. Clin Endocrinol 2009; 71: 529–568
10. Street ME, Volta C, Ziveri MA et al. Changes and relationships of IGFS and IGFBPS and cytokines in coeliac disease at diagnosis and on gluten-free diet. Clin Endocrinol (Oxf) 2008; 68: 22–28
11. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study Group. Lancet 1994; 344: 1383–1389
12. Arrigo T, Wasniewska M, Crisafulli G et al. Subclinical hypothyroidism: the state of the art. J Endocrinol Invest 2008; 31: 79–84
13. Szybiński Z.Polish council for control of iodine deficiency disorders. Work of the Polish council for control of iodine deficiency disorders, and the model of iodine prophylaxis in Poland. Endokrynol Polska 2012; 63: 156–320
14. Muller AF, Drexhage HA, Berghout A. Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: Recent insights and consequences for antenatal and postnatal care. Endocr Rev 2001; 22: 605–630
15. Kłapcińska B, Poprzecki S, Danch A et al. Selenium levels in blood of Upper Silesian population: Evidence of suboptimal selenium status in a significant percentage of the population. Biol Trace Elem Res 2005; 108: 1–15
16. Hinks LJ, Inwards KD, Lloyd B et al. Body content of selenium in coeliac disease. Br Med J (Clin Res Ed) 1984; 288: 3662–3663
17. Kalita B, Nowak P, Slimok M et al. Selenium plasma concentrations in children with celiac disease in different stages of diagnosis. Pol Merkur Lekarski 2002; 12: 43–44
18. Hurst R, Collings R, Harvey LJ et al. EURRECA-estimating selenium requirements for deriving dietary reference values. Crit Rev Food Sci Nutr 2012; 53: 1077–1096
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Kanhaiya Prasad
Assistant professor, Department of Medicine ,Govt. Medical College and super facility hospital, Charkrapanpur, Azamgarh Uttar Pradesh 276128