“A STUDY OF CREATINE KINASE LACTATE DEHYDROGENASE ACTIVITY IN THYROID DISORDERS CASES AND IN HEALTHY CONTROLS.”
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Keywords
Thyroid Disorder, Creatine Kinase, Lactate Dehydrogenase
Abstract
Background: Thyroid function plays a crucial role in regulating various metabolic processes, including lipoprotein metabolism and cardiovascular disease (CVD) risk factors, ultimately influencing overall CVD risk. Hypothyroidism can lead to a decline in muscle creatine levels, contributing to thyroid myopathy. This condition is characterized by primary muscle involvement, resulting in slowed muscle contraction and relaxation, muscle pain, and proximal muscle weakness.
Aim: The present study was aimed to evaluate creatine kinase and lactate dehydrogenase activity in thyroid disorders and control subjects.
Materials & Methods: A hospital-based case-control study was conducted over a period of one year to investigate the relationship between thyroid disorders and muscle enzyme activity. The study included 200 cases of thyroid disorders (100 cases of Hypothyroidism and 100 cases of Hyperthyroidism), aged 20-60 years, and 100 healthy controls. Serum creatine kinase and lactate dehydrogenase activity were measured in all participants, and the results were compared and analysed using SPSS software 23.0 version.
Results: The study revealed significant differences in weight and BMI, with the hyperthyroidism group having higher values compared to the hypothyroidism and control groups (p<0.05). Additionally, overt hypothyroidism was characterized by elevated TSH levels and LDH activity, while subclinical hypothyroidism showed increased T3, T4, and CK levels. The thyroid profile (TSH, T3, and T4) differed significantly between subclinical and overt hypothyroidism (p<0.05), whereas CK and LDH activity showed no significant differences (p>0.05).
Conclusion: It can be concluded that elevated levels of CK and LDH enzymes can serve as indicators of cellular necrosis and tissue damage, warranting consideration of hypothyroidism in patients with myopathy and unexplained elevation of serum muscle enzymes. The study also reveals that hypothyroidism commonly affects individuals in their third and fourth decades of life, with a higher prevalence among females. Furthermore, CK and LDH activity may be useful as supplemental diagnostic tools and prognostic metrics for hypothyroid diseases, and their considerable increase suggests potential utility in screening for thyroid dysfunction.
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Dr. Akanksha Srivastava
PhD. Medical Biochemistry from RBB Subharti University Dehradun.
Miss Manisha Bhardwaj
PhD. Scholar, Department of Biochemistry, KM University, Mathura.