A COMPREHENSIVE REVIEW ON PHYTOCHEMICALS WITH ANTI-DIABETIC ACTIVITY: MECHANISMS AND APPLICATIONS
Main Article Content
Keywords
Phytochemicals, Diabetes mellitus, Insulin resistance, Antioxidants, Natural products, Drug discovery
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by impaired glucose homeostasis, insulin resistance, and long-term complications affecting multiple organ systems. The search for effective and safer alternatives to conventional antidiabetic drugs has led to growing interest in phytochemicals derived from medicinal plants. Phytochemicals such as flavonoids, alkaloids, phenolics, terpenoids, and glycosides have demonstrated significant antidiabetic potential through diverse mechanisms, including inhibition of carbohydrate-digesting enzymes, enhancement of insulin secretion, and modulation of glucose uptake and antioxidant activity. This review comprehensively explores the diverse classes of phytochemicals with antidiabetic properties, highlighting their mechanisms of action, pharmacological potential and clinical relevance. Further, the application of these bioactive compounds in functional foods, nutraceuticals and pharmaceutical formulations is discussed, along with challenges such as bioavailability, toxicity, and regulatory considerations. The integration of phytochemicals in diabetes management holds promise for the development of novel, plant-based therapeutics, paving the way for improved treatment strategies.
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Feb 28, 2025
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S. Velmurugan, S. Seshai, V.J. Ramachandiran, A. Reshma, S. Anbazhagan, & S. A. Vadivel. (2025). A COMPREHENSIVE REVIEW ON PHYTOCHEMICALS WITH ANTI-DIABETIC ACTIVITY: MECHANISMS AND APPLICATIONS. Journal of Population Therapeutics and Clinical Pharmacology, 32(1), 1451-1471. https://doi.org/10.53555/hqaw2e18
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Author Biographies
S. Velmurugan
Research student, Surya School of Pharmacy, Villupuram.
S. Seshai
Research student, Surya School of Pharmacy, Villupuram.
V.J. Ramachandiran
Research student, Surya School of Pharmacy, Villupuram.
A. Reshma
Research student, Surya School of Pharmacy, Villupuram.
S. Anbazhagan
Professor, Department of Pharmaceutical Chemistry. Surya School of Pharmacy, Villupuram.
S. A. Vadivel
Associate Professor, Department of Pharmaceutics, Surya School of Pharmacy, Villupuram.
How to Cite
S. Velmurugan, S. Seshai, V.J. Ramachandiran, A. Reshma, S. Anbazhagan, & S. A. Vadivel. (2025). A COMPREHENSIVE REVIEW ON PHYTOCHEMICALS WITH ANTI-DIABETIC ACTIVITY: MECHANISMS AND APPLICATIONS. Journal of Population Therapeutics and Clinical Pharmacology, 32(1), 1451-1471. https://doi.org/10.53555/hqaw2e18