INTRACAMERAL CEFUROXIME INDUCED RETINAL INFARCTION IN POST-OPERATIVE CATARACT SURGERY - A DISPROPORTIONALITY ANALYSIS IN FOOD AND DRUG ADMINISTRATION ADVERSE EVENT REPORTING SYSTEM DATABASE
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Keywords
Intracameral Cefuroxime, Retinal Infarction, Cataract Surgery, FAERS.
Abstract
OBJECTIVES: During intraocular surgery, cefuroxime is frequently used to prevent post-operative endophthalmitis. Retinal infarction is a possible adverse reaction to its intracameral administration. Retinal infarction is the loss of visual acuity or a part of retina because of interruption of blood flow in retina. This study aims to evaluate the potential association between intracameral cefuroxime and retinal infarction by reviewing case studies and conducting a disproportionality analysis of spontaneous reports.
METHODS: A retrospective case/non-case study was conducted using spontaneous reports from the Food and Drug Administration Adverse Event Reporting System (FAERS). Disproportionality analysis was performed by calculating the Proportional Reporting Ratio (PRR), Reporting Odds Ratio (ROR), Relative Risk Reduction (RRR) and Chi Square test.
RESULTS: A total of 43 spontaneous reports of retinal infarction suspected to be caused by intracameral cefuroxime were identified from FAERS database. Through the disproportionate analysis of FAERS data, a signal was identified between retinal infarction and intracameral cefuroxime having ROR of 489.674 (333.052; 719.948), PRR of 486.907 (331.741; 714.651), RRR 383.456 (263.576; 557.86) and Chi-squared value is 12215.552 values respectively showing a positive signal.
CONCLUSION: The current investigation indicated that intracameral cefuroxime may increase the incidence of retinal infarction. It is essential to fully evaluate the situation and to take steps to prevent or mitigate the risk.
References
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Dr. Akshara C.R.
Clinical Pharmacist, Department of Clinical Pharmacy,Ramaiah Medical College Hospital, Bangalore, Karnataka, India.
Dr. Deepak Kumar Jain I.
Clinical Pharmacist, Department of Clinical Pharmacy, Ramaiah Medical College Hospital, Bangalore, Karnataka, India.
Dr. Tenzing Whesal Bhutia
Faculty of Health Sciences, MSc Global Public Health Student.