UNVEILING THE THERAPEUTIC POTENTIAL OF CORIANDRUM SATIVUM LEAVES: ANTIDIABETIC, ANTIPYRETIC, AND ANTIMICROBIAL INSIGHTS
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Abstract
The present study was designed to investigate and establish the folklore uses of Coriandrum sativum (Linn) as antidiabetic, antipyretic and antimicrobial agent. The antidiabetic activity of methanolic extract of Coriandrum sativum was studied in alloxan induced diabetic rats at the doses of 200 and 400mg/kg body weight for the period of 21 days and its effect on blood– glucose, serum insulin and lipid profile was estimated during the study.
Paracetamol (150mg/kg body weight by oral) was used as reference drug and control group received 2% Tween 80. Rectal temperatures of all rats were recorded and compared at 19h immediately before extract or paracetamol or vehicle administration and again at 1 h interval up to 23 h. The CSLE ( 200 and 400mg/kg by oral ) showed significant and dose dependent reduction in pyrexia. The extract had shown a significant dose dependent antipyreic effect comparable with standard drug paracetamol.
The extract was found to possess a significant antibacterial effect against Gram -ve (E.coli, Shigella spp, Vibrio spp) appeared to be most susceptible to CSLE than the gram positive (Bacillus spp, S. aureus) organisms. The minimum inhibitory concentration (m.i.c) and zone of inhibition (in mm) was determined by checker board technique and disc diffusion technique respectively.
The extract was found to possess a significant antifungal effect against various strains of Candida. It was found that Candida albicans ATCC-10231 and Candida albicans 5 were completely inhibited at 200 µg/ml. Inhibition of growth of Penicillin notatum started at 100 µg/ml and was completely inhibited at 400 µg/ml.
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Mohit Kotnala
Assistant Professor, Pharmacy Institute NIET (Noida Institute of Engineering and Technology) Greater Noida.
Kanupriya Sharma
Biology Teacher, J.M International School, Dwarka Sector 6, Delhi, India