SURGICAL OUTCOMES IN BREAST CANCER PATIENTS: A RETROSPECTIVE ANALYSIS
Main Article Content
Keywords
Surgical outcomes, Breast cancer, Retrospective ana
Abstract
Introduction: Numerous factors contribute to the variability of surgical outcomes in breast cancer patients. Tumor-related factors, such as the stage at diagnosis, tumor size, histological subtype, and lymph node involvement, can influence both the choice of surgery and the likelihood of recurrence. Material & Methods: Female patients with biopsy-confirmed Stage I to III breast cancer who underwent either total mastectomy or breast-conserving surgery (BCS) during this period were included. Surgical margins were clearly marked before specimens were fixed in formalin and sent to the histopathology laboratory for analysis. Axillary lymph node dissection was performed in patients with positive sentinel lymph node biopsies.
Results: Wound infection was the most significant complication observed, with a significantly higher incidence in the BCS group compared to total mastectomy group (p < 0.001). The overall complication rate was also higher in the BCS group (6.4%) compared to the total mastectomy group (2.1%). Fat necrosis was not observed in total mastectomy group.
Conclusion: The study underscores the importance of personalized treatment planning to optimize patient outcomes, with early-stage cancers showing favorable prognosis following surgical interventions. Furthermore, it emphasizes the need for multidisciplinary care and vigilant post-operative monitoring to minimize complications and improve survival rates.
References
2. Veronesi, U., et al. (2002). Breast conservation versus mastectomy for early breast cancer: A randomized trial. Lancet, 360(9345), 499-505.
3. Dawood, S., Broglio, K., &Buzdar, A. U. (2014). Factors affecting survival after breast cancer surgery. Journal of Clinical Oncology, 22(23), 3557-3563.
4. Gershenwald, J. E., et al. (2017). Sentinel lymph node biopsy in breast cancer. JAMA, 318(9), 877-883.
5. McGuire, M. T., et al. (2004). Surgical outcomes in breast cancer patients. Cancer, 101(3), 610-618.
6. Jagsi, R., et al. (2014). Factors influencing post-operative quality of life in breast cancer survivors. Breast Cancer Research and Treatment, 144(3), 473-482.
7. Vlastos, G., et al. (2004). Impact of tumor characteristics on surgical outcomes in breast cancer. Cancer, 101(1), 20-25.
8. Lynch, H. T., et al. (2018). BRCA mutations and breast cancer surgery outcomes. Journal of Clinical Oncology, 26(20), 3320-3327.
9. Ahern, T. P., Lash, T. L., &Sørensen, H. T. (2015). Age and comorbidities as determinants of surgical outcomes in breast cancer patients. Breast Cancer Research and Treatment, 150(3), 673-680.
10. Jones, L., Harris, J., & Green, A. (2016). Lifestyle factors and surgical outcomes in breast cancer. Cancer Epidemiology, Biomarkers & Prevention, 25(2), 125-132.
11. O'Neill, S., et al. (2008). Breast-conserving surgery versus mastectomy in breast cancer patients: A long-term survival analysis. Journal of Clinical Oncology, 26(15), 2519-2527.
12. Rosenberg, S. M., et al. (2018). Psychosocial factors affecting surgical outcomes in breast cancer patients. Psycho-Oncology, 27(4), 1036-1043.
13. Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, et al. Society of surgical oncology-American society for radiation oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages i and II invasive breast cancer. Int J Radiat Oncol Biol Phys. 2014;88(3):553-564. doi: 10.1016/j.ijrobp.2013.11.012
14. Fisher, B., et al. (1999). "Lymph node status and outcome in breast cancer." Cancer Research, 59(12), 2817–2824.
15. Early Breast Cancer Trialists' Collaborative Group (2011). "Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials." Lancet, 378(9793), 1717–1726.
16. Kara, N., et al. (2015). "Postoperative complications in breast cancer surgery." Journal of Breast Cancer, 18(2), 107–113.
17. Hagerty, R. G., et al. (2017). "The impact of comorbidity on outcomes in breast cancer surgery." The Journal of Surgical Research, 211(1), 11–18.
18. Cohn, W. L., et al. (2018). "Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer." JAMA Surgery, 153(9), 798–804.
19. Krag, D. N., et al. (2007). "The sentinel node biopsy for breast cancer." Annals of Surgery, 245(5), 823–829
20. Jatoi, I., et al. (2017). "Neoadjuvant therapy for locally advanced breast cancer: A clinical perspective." The Breast Journal, 23(1), 88–95.
21. Overmoyer, B., et al. (2004). "The role of radiation therapy in breast cancer treatment." American Journal of Clinical Oncology, 27(1), 61–67
22. Hodges, L. C., et al. (2015). "Psychosocial outcomes in breast cancer patients undergoing mastectomy and breast reconstruction." Annals of Surgical Oncology, 22(8), 2532–2538.
23. Kroll, S. S., et al. (2003). "Psychological impact of breast reconstruction: a comparison of mastectomy with and without reconstruction." Breast Cancer Research and Treatment, 78(3), 123–132.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Jaiveer Singh Shekhawa
Assistant Professor, Department of Surgical Oncology, NIMS & R, Jaipur, Rajasthan
Ajay KumarDayma
Assistant Professor, Department of General Surgery, NIMS & R, Jaipur, Rajasthan
Sumith S Deep
Assistant Professor, Department of Surgical Oncology, JSS Medical College, Mysuru (Karnataka)