WATER QUALITY AND GASTROINTESTINAL DISEASE, PHYSIOLOGICAL IMPACT ON GUT FUNCTION

Main Article Content

Nabeela Yasmeen
Muhammad Israr Ul Haq
Ghazala Yasmeen Iqbal
Hafiz Umer Farooq
Rafay Ur Rehman Cheema
Shazia Sultan

Keywords

Water quality, gastrointestinal diseases, gut health, microbial contamination, Pakistan, dysbiosis

Abstract

Objectives
This study aims to assess the impact of water quality on gastrointestinal diseases and the physiological effects on gut function, with a focus on rural and urban populations in Pakistan.
Materials and Methods
Cross-sectional study was carried out at more than one place in Pakistan, water samples were collected and tested for microbial and chemical quality. Gut symptoms were assessed in study participants, and fecal samples collected to assess microbiota profile and inflammation.
Results
The findings showed high levels of water pollution by pathogens which has enhanced the incidence of gastrointestinal diseases particularly in the rural population. It was further observed that the levels of chemical in the urban area were significantly high which had negative impact on the dysbiosis and gut health. A positive correlation between water quality and incidences of diarrhoeal disorders, flatulence and other stomach upsets was established by the study.
Conclusion
The study underscores the critical need for improved water treatment and monitoring systems to reduce waterborne diseases and safeguard gut health.

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References

1- Kord, M.I., Maulu, S., Srour, T.M., Omar, E.A., Farag, A.A., Nour, A.A.M., Hasimuna, O.J., Abdel-Tawwab, M. and Khalil, H.S., 2022. Impacts of water additives on water quality, production efficiency, intestinal morphology, gut microbiota, and immunological responses of Nile tilapia fingerlings under a zero-water-exchange system. Aquaculture, 547, p.737503.
2- Savarino, E., Zingone, F., Barberio, B., Marasco, G., Akyuz, F., Akpinar, H., Barboi, O., Bodini, G., Bor, S., Chiarioni, G. and Cristian, G., 2022. Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. United European gastroenterology journal, 10(6), pp.556-584.
3- Tavakoli, P., Vollmer-Conna, U., Hadzi-Pavlovic, D. and Grimm, M.C., 2021. A review of inflammatory bowel disease: a model of microbial, immune and neuropsychological integration. Public health reviews, 42, p.1603990.
4- Yukgehnaish, K., Kumar, P., Sivachandran, P., Marimuthu, K., Arshad, A., Paray, B.A. and Arockiaraj, J., 2020. Gut microbiota metagenomics in aquaculture: factors influencing gut microbiome and its physiological role in fish. Reviews in Aquaculture, 12(3), pp.1903-1927.
5- Sehnal, L., Brammer-Robbins, E., Wormington, A.M., Blaha, L., Bisesi, J., Larkin, I., Martyniuk, C.J., Simonin, M. and Adamovsky, O., 2021. Microbiome composition and function in aquatic vertebrates: small organisms making big impacts on aquatic animal health. Frontiers in Microbiology, 12, p.567408.
6- Wickramasuriya, S.S., Park, I., Lee, K., Lee, Y., Kim, W.H., Nam, H. and Lillehoj, H.S., 2022. Role of physiology, immunity, microbiota, and infectious diseases in the gut health of poultry. Vaccines, 10(2), p.172.
7- Jha, R., Das, R., Oak, S. and Mishra, P., 2020. Probiotics (direct-fed microbials) in poultry nutrition and their effects on nutrient utilization, growth and laying performance, and gut health: A systematic review. Animals, 10(10), p.1863.
8- Karakan, T., Ozkul, C., Küpeli Akkol, E., Bilici, S., Sobarzo-Sánchez, E. and Capasso, R., 2021. Gut-brain-microbiota axis: antibiotics and functional gastrointestinal disorders. Nutrients, 13(2), p.389.
9- Zhao, X., Jiang, L., Fang, X., Guo, Z., Wang, X., Shi, B. and Meng, Q., 2022. Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs. Microbiome, 10(1), p.115.
10- Mekhael, M., Kristensen, H.Ø., Larsen, H.M., Juul, T., Emmanuel, A., Krogh, K. and Christensen, P., 2021. Transanal irrigation for neurogenic bowel disease, low anterior resection syndrome, faecal incontinence and chronic constipation: a systematic review. Journal of clinical medicine, 10(4), p.753.
11- Zhang, P., 2022. Influence of foods and nutrition on the gut microbiome and implications for intestinal health. International journal of molecular sciences, 23(17), p.9588.
12- Hodgkinson, K., El Abbar, F., Dobranowski, P., Manoogian, J., Butcher, J., Figeys, D., Mack, D. and Stintzi, A., 2023. Butyrate’s role in human health and the current progress towards its clinical application to treat gastrointestinal disease. Clinical Nutrition, 42(2), pp.61-75.
13- Gasaly, N., Hermoso, M.A. and Gotteland, M., 2021. Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases. International journal of molecular sciences, 22(6), p.3061.
14- Bancil, A.S., Sandall, A.M., Rossi, M., Chassaing, B., Lindsay, J.O. and Whelan, K., 2021. Food additive emulsifiers and their impact on gut microbiome, permeability, and inflammation: mechanistic insights in inflammatory bowel disease. Journal of Crohn's and Colitis, 15(6), pp.1068-1079.
15- Liu, Y., Li, Y., Yu, X., Yu, L., Tian, F., Zhao, J., Zhang, H., Zhai, Q. and Chen, W., 2020. Physiological characteristics of Lactobacillus casei strains and their alleviation effects against inflammatory bowel disease. Journal of Microbiology and Biotechnology, 31(1), p.92.