A PRECLINICAL INVESTIGATION TO EVALUATE THE EFFECTIVENESS OF AYURVEDIC INTERVENTION IN KAPHAJA LINGANASHA (CATARACT)

Abstract

Background: This study investigates the potential anticataract effects of Netraum Anjan eye drops as an alternative treatment for cataracts, a leading cause of blindness worldwide. The study evaluates the efficacy of Netraum Anjan eye drops in a controlled rat model, providing insights into its therapeutic potential for cataract management.

Objective: The objective is to evaluate the cataract preventive action of the test substance Netraum Anjan against Naphthalene-induced experimental Rats.

Materials and Methods: Forty albino Rats in five groups were used to study anticataract activity. Netraum Anjan Eye Drop (single and double application) and Vitamin E (50 mg/kg) served as standards, while normal saline was the control. The test substance was administered with naphthalene for 42 days to induce cataracts (0.5 g/kg for 3 days, then 1 g/kg for 42 days).

Results: Forty Wistar albino rats were divided into five groups to assess the anticataract effect of Netraum Anjan Eye Drop against naphthalene-induced cataracts. Naphthalene administration for 42 days depleted glutathione (GSH) levels, causing oxidative stress and cataract formation. Treatment with Vitamin E (50 mg/kg) and low- and high-dose Netraum Anjan Eye Drop significantly restored GSH levels compared to the pathological control.

Conclusion: This study concludes that Netraum Anjan eye drops significantly inhibit cataract development. The findings suggest that the test substance offers promising cataract prevention and management potential.