FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DEFLAZACORT
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Keywords
Deflazacort, Eudragit S 100, Ethyl Cellulose, Hydroxypropyl Cellulose and Controlled Release Tablets
Abstract
In the present work, an attempt has been made to develop controlled release tablets of Deflazacort by selecting different types of polymers Eudragit S 100, Ethyl Cellulose and Hydroxypropyl Cellulose as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F8 formulation showed maximum % drug release i.e., 96.94 % in 12 hours. Hence it is considered as optimized formulation F8 which contains Hydroxypropyl Cellulose (10 mg). Whereas the formulations with Eudragit S 100 showed more retarding with low concentration of polymer.
References
2. Reddy KR., Mutalik S, Reddy S. AAPS Pharm. Sci. Tech.2003; 4: 19. 121-125.
3. Mohammed AD et al. Release of propranolol hydrochloride from matrix tablets containing sodium carboxymethylcellulose and Hydroxypropyl methyl cellulose. Pharm Dev Tech.1999; 4: 313-324.
4. Salsa T, Veiga F. Drug Develop. Ind Pharm. 1997; 23: 931.
5. Jantzen GM, Robinson JR, Sustained and controlled-release drug delivery systems, inBanker GS, Rhodes CT (Eds.) Modern Pharmaceutics, 3rd Ed, Revised andExpanded, Drugs and the Pharmaceutical Sciences., Marcell Dekker, Inc. NewYork. 1995; 72: 575-609.
6. Jantzen GM, Robinson JR. Sustained and Controlled- Release Drug Delivery systems Modern Pharmaceutics, 4thed; 2003; 121: 501-502.
7. Lee BJ, Ryu SG, Cui JH, Drug Dev. Ind.Pharm.1999; 25: 493-501.
8. Gwen MJ, Joseph RR, In Banker GS and Rhodes CT, Ed. Modern Pharmaceutics, 3rdEd Marcel Dekker Inc. New York. 1996; 72: 575.
9. Vidyadhara S, Rao PR, Prasad JA. Indian J Pharm Sci. 2004; 66: 188-192.
10. Bogner RH. Bioavailability and bioequivalence of extended-release oral dosage forms. US Pharmacist. 1997; 22: 3–12.
11. Rogers JD, Kwan KC. Pharmacokinetic requirements for controlled-release dosage forms. In: John Urquhart, ed. Controlled-release Pharmaceuticals. Academy of Pharmaceutical Sciences. American Pharmaceutical Association. 1979: 95–119.
12. Madan PL. Sustained-release drug delivery systems, part II: Preformulation considerations. Pharm Manu fact. 1985; 2: 41–45.
13. Wani MS, Controlled Release System-A Review, 2008; 6 1: 56-62.
14. Banker GS, Anderson NR. The Theory and Practice of Industrial Pharmacy: Tablet,Lachman, (3rded) Varghese Publishing House, Bombay. 1990; 3: 293-303.
15. Lee VHL, Controlled Drug Delivery Fundamentals and Applications: Influence of drug properties on design, Marcel Dekker, INC, and New York. 1987; 2: 16-29.
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Fouzia Sultana
Department Of Pharmaceutics, Samskruti College Of Pharmacy In Ghatkesar, Telangana. 501301.
Y. Sirisha
Department Of Pharmaceutics, Samskruti College Of Pharmacy In Ghatkesar, Telangana. 501301.
K. Nagasree
Department Of Pharmaceutics, Samskruti College Of Pharmacy In Ghatkesar, Telangana. 501301.