“ASSOCIATION OF ANXIETY AND DEPRESSION ON CHRONIC KIDNEY DISEASE PATIENTS AFFECTING QUALITY OF LIFE”

Main Article Content

Naeem Amjad1
Kanza Hamid
Ammad Ahmad Siddiqui
Muhammad Aamir
Muhammad Haroon Ghous
Syeda Sabeen Fatima

Keywords

Anxiety, Depression, Chronic Kidney disease, Quality of life, Psychological distress

Abstract

Introduction:


Chronic kidney disease (CKD) is a widespread, progressive disorder characterized by the gradual loss of kidney function over time. Affecting approximately 10% of the global population, CKD imposes a significant burden on individuals and healthcare systems alike. The condition is typically accompanied by a range of physical complications, including hypertension, anemia, bone disorders, and cardiovascular disease. However, beyond its physiological manifestations, CKD exerts a profound psychological and emotional toll on patients, profoundly influencing their quality of life (QoL).


Objective:


To examine the relationship between anxiety, depression, and quality of life in CKD patients


 


Material and Methods:


A cross-sectional study was conducted to examine the prevalence and impact of anxiety and depression on the quality of life among CKD patients. Data were collected from a representative sample of 250 individuals aged 18 years and above were recruited. Descriptive statistics, correlation analysis, and multivariate regression were used to determine the relationship between anxiety, depression, and QoL.


Results:


There were 250 participants who included in this research after inclusion and exclusion criteria in which 140 were male and 110 were females in which 55% exhibited clinically anxiety and 45% marked as depression. Patients with higher anxiety and depression scores had significantly lower QoL scores across all dimensions. The strongest negative correlations were observed in the emotional well-being (-0.72, p < 0.01) and physical health (-0.57, p < 0.01) domains. Regression analysis identified depression (p < 0.01), anxiety (p < 0.05), and lower socioeconomic status (p < 0.05) as significant predictors of poor QoL.


 


Conclusion:


The association between anxiety, depression and CKD underscores the importance of a holistic approach to patient care. Addressing mental health in CKD patients is not just about improving psychological well-being it is a critical component of enhancing overall QoL and clinical outcomes. By integrating mental health assessments and interventions into routine CKD management, healthcare providers can help patients navigate the challenges of their condition more effectively, ultimately improving their quality of life.

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References

1. Lee YJ, Kim M, Cho S, Kim S. Association of depression and anxiety with reduced quality of life in patients with predialysis chronic kidney disease. International journal of clinical practice. 2013;67(4):363-8.
2. Sousa L, Valentim O, Marques-Vieira C, Antunes AV, Sandy S, José H. Association between stress/anxiety, depression, pain and quality of life in people with chronic kidney disease. 2020.
3. Hong YS, Kim H, Zhao D, Cho A. Chronic kidney disease on health-related quality of life in patients with diabetes mellitus: a national representative study. Journal of Clinical Medicine. 2021;10(20):4639.
4. Wang W-L, Liang S, Zhu F-L, Liu J-Q, Wang S-Y, Chen X-M, et al. The prevalence of depression and the association between depression and kidney function and health-related quality of life in elderly patients with chronic kidney disease: a multicenter cross-sectional study. Clinical Interventions in Aging. 2019:905-13.
5. Bujang MA, Musa R, Liu WJ, Chew TF, Lim CT, Morad Z. Depression, anxiety and stress among patients with dialysis and the association with quality of life. Asian journal of psychiatry. 2015;18:49-52.
6. Alshelleh S, Alhouri A, Taifour A, Abu-Hussein B, Alwreikat F, Abdelghani M, et al. Prevelance of depression and anxiety with their effect on quality of life in chronic kidney disease patients. Scientific Reports. 2022;12(1):17627.
7. Al‐Nashri F, Almutary H. Impact of anxiety and depression on the quality of life of haemodialysis patients. Journal of clinical nursing. 2022;31(1-2):220-30.
8. Voorend C, Van Oevelen M, Nieberg M, Meuleman Y, Franssen C, Joosten H, et al. Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease. BMC geriatrics. 2021;21:1-10.
9. Işık Ulusoy S, Kal Ö. Relationship among coping strategies, quality of life, and anxiety and depressive disorders in hemodialysis patients. Therapeutic Apheresis and Dialysis. 2020;24(2):189-96.
10. Nagy E, Tharwat S, Elsayed AM, Shabaka SAE-G, Nassar MK. Anxiety and depression in maintenance hemodialysis patients: prevalence and their effects on health-related quality of life. International Urology and Nephrology. 2023;55(11):2905-14.
11. Cheng J, Yang D, Zuo Q, Peng W, Zhu L, Jiang X. Correlations between uncertainty in illness and anxiety, depression and Quality of life in patients receiving maintenance haemodialysis: A cross‐sectional study. Nursing Open. 2022;9(2):1322-31.
12. Abrão RO, Lopes M, Silva GJ, Ferraro AA, Koch VH. Study of the association between generic and disease-specific quality of life and behavior problems in pediatric patients with chronic kidney disease stage 3 or higher and the quality of life and mental health of their primary caregivers. Pediatric Nephrology. 2021;36:3201-10.
13. Mosleh H, Alenezi M, Alsani A, Fairaq G, Bedaiwi R. Prevalence and factors of anxiety and depression in chronic kidney disease patients undergoing hemodialysis: a cross-sectional single-center study in Saudi Arabia. Cureus. 2020;12(1).
14. Yaseen M, Jarullah FA, Yaqoob S, Shakeel HA, Maqsood H, Naveed S. Association of quality of life, anxiety, and depression with restless leg syndrome in the hemodialysis patients. BMC Research Notes. 2021;14:1-6.
15. Kim O, Yeom EY, Jeon HO. Relationships between depression, family function, physical symptoms, and illness uncertainty in female patients with chronic kidney disease. Nursing & Health Sciences. 2020;22(3):548-56.
16. Fletcher BR, Damery S, Aiyegbusi OL, Anderson N, Calvert M, Cockwell P, et al. Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis. PLoS medicine. 2022;19(4):e1003954.
17. Khan S, Ahmad I. Impact of hemodialysis on the wellbeing of chronic kidney diseases patients: a pre-post analysis. Middle East Current Psychiatry. 2020;27(1):54.

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