SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRIMIDINE DERIVATIVES
Main Article Content
Keywords
Benzenesulfonohydrazide, Tetrahydropyrimidone, 5-nitro furfural, antimicrobial activity and spectral studies
Abstract
Benzenesulfonohydrazide (1) on reaction with Ethyl acetoacetate (2) yield N'-(3-oxobutanoyl) benzene sulfonohydrazide(3). Then the compound(3) reacted with various aromatic aldehydes (4a-g) and Urea (5) yielded N'-(6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbonyl)benzenesulfonohydrazide (6a-g). The compounds (6a-g) further reacted with 5-nitro furfural (7) yields N'-(3-(hydroxy(5-nitrofuran-2-yl)methyl)-6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbonyl)benzenesulfonohydrazide (8a-g). The structures of both the series of compounds (6a-g) and (8a-g) were characterized structurally by spectral features. The compounds were also monitored for anti microbial activity.
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Published
Dec 06, 2022
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How to Cite
Naga Venkata Raghavulu Dusanapudi, Piyush. J. Vyas, & Saisuryanarayana Donthukurthi. (2022). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRIMIDINE DERIVATIVES. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 4681-4687. https://doi.org/10.53555/8kvrcg54
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Author Biographies
Naga Venkata Raghavulu Dusanapudi
Sheth M.N. Science Collge, Patan, Gujarat, India
Piyush. J. Vyas
Sheth M.N. Science Collge, Patan, Gujarat, India
Saisuryanarayana Donthukurthi
Sheth M.N. Science Collge, Patan, Gujarat, India
How to Cite
Naga Venkata Raghavulu Dusanapudi, Piyush. J. Vyas, & Saisuryanarayana Donthukurthi. (2022). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRIMIDINE DERIVATIVES. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 4681-4687. https://doi.org/10.53555/8kvrcg54