FORMULATION AND EVALUATION OF ORO DISPERSIBLE FILMS OF ETORICOXIB USING POLYVINYL ALCOHOL
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Keywords
Oro Dispersible Films, Arthritis, Etrocoxibe, PVA
Abstract
The goal of the current study is to develop orodispersible films containing etoricoxib to improve therapeutic efficacy by improving patient compliance and convenience for both younger and older patients. Varied batches of Oro-dispersible films (ODF) of etoricoxib were produced by the solvent casting process using varied quantities of PVA, sodium starch glycolate, sodium, saccharine, vanillin, and purified water. The films were then assessed for appearance, weight variation, thickness, folding endurance, drug content, disintegration time, and in vitro drug release. The optimized formulation A5 exhibited acceptable folding endurance (more than 25), least disintegration time (50seconds), highest drug content (55.18 mg) and highest drug release (103.6±0.12 %) in 10minutes. The study concludes that formulation A4 of Oro Dispersible Films for sublingual delivery of etrocoxibe may be an optimal formulation. The developed formulation can be a unique dosage form to improve drug release, beginning of action, and patient compliance. The optimized formulation yields satisfactory results.
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Dhaneshwar Kumar Vishwakarma
Research Scholar School of Pharmaceutical Sciences, IFTM University Moradabad
NavneetVerma
School of Pharmaceutical Sciences, IFTM University Moradabad