SKIN TOXICITIES AND ALLERGIC REACTIONS ASSOCIATED WITH BOTULIN TOXIN INJECTION FOR AESTHETIC PROCEDURES

Main Article Content

Dr Iqra Jamshaid
Dr Palwasha Ishaque
Dr Amber Shami
Dr Nishwah Khan
Dr Sana Usman
Dr Sara Gull

Keywords

Skin Toxicities, Allergic Reactions, Aesthetic Procedures

Abstract

Introduction: Cosmetic surgery procedures have increased manifolds all over the world owing to the ever-increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well-defined, and lasting results for the reduction of facial fine lines, wrinkles, and facial rejuvenation.


Objectives: The main objective of the study is to find the skin toxicities and allergic reactions associated with botulin toxin injection for aesthetic procedures.


Methodology: This observational study was conducted at Karachi with the collaboration of different aesthetic clinics in Islamabad during June 2023 to June 2024.  No interventions or modifications were made to the standard clinical practices followed by the healthcare providers administering the injections. Patients who opted for botulinum toxin injections for aesthetic purposes such as wrinkle reduction or facial rejuvenation were included in the study.


Results: Data were collected from 55 patients with a majority being female (76%) and the largest age group being 31-40 years (36%). Skin reactions occurred in 11% of patients, with redness being the most common reaction (5.5%), followed by swelling (3.5%) and itching (2%).


Conclusion: It is concluded that botulinum toxin injections for aesthetic purposes have a generally favourable safety profile, with mild and transient skin toxicities and allergic reactions occurring in a small percentage of patients.


 

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References

1. Owczarczyk-Saczonek A, Zdanowska N, Wańczyk-Dręczewska B, et al. Pyoderma gangrenosum-like lesions provocated by botulinum injections. Dermatol Ther. 2020; 33.
2. D’Souza A, Ng CL. Applied anatomy for botulinum toxin injection in cosmetic interventions. Curr Otorhinolaryngol Rep. 2020; 8: 336-343.
3. Olivieri P, Uribe FA, Quereshy FA. Aesthetic facial surgery and orthodontics: common goals. Oral Maxillofac Surg Clin North Am. 2020; 32: 153-165.
4. Park JY, Byun EJ, Kim HS. Rejuvenation of periocular region in Koreans: A multimodal approach combining botulinum toxin, fillers, and micro-focused ultrasound with visualization for optimal results. Dermatol Ther. 2019; 33.
5. Aksu AD. Cosmetical treatments of connective tissue disorders. Dermatol Ther. 2019; 32(4).
6. Satriyasa BK. Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect. Clin Cosmet Investig Dermatol. 2019; 12: 223-228.
7. Cho YM, Kim SG, Choi DS, Jang I, Cha BK. Botulinum toxin injection to treat masticatory movement disorder corrected mandibular asymmetry in a growing patient. J Craniofac Surg. 2019; 30: 1850-1854.
8. Kattimani V, Tiwari RVC, Gufran K, Wasan B, Shilpa PH, Khader AA. Botulinum toxin application in facial esthetics and recent treatment indications (2013–2018). J Int Soc Prev Community Dent. 2019; 9: 99-105.
9. Yeh YT, Peng JH, Peng HL. Literature review of the adverse events associated with botulinum toxin injection for the masseter muscle hypertrophy. J Cosmet Dermatol. 2018; 17: 675-687.
10. Wollina U, Goldman A. Botulinum toxin A and/or soft tissue fillers for facial rehabilitation. Wien Med Wochenschr. 2017; 167: 92-95.
11. França K, Castillo D, Lotti T. Non-cosmetic dermatological use of botulinum neurotoxin. Dermatol Ther. 2017; 30(4):12495.
12. Zhu J, Ji X, Xu Y, et al. The efficacy of intradermal injection of type A botulinum toxin for facial rejuvenation. Dermatol Ther. 2017; 30(1):12433.
13. de Maio M, Swift A, Signorini M, Fagien S. Aesthetic Leaders in Facial Aesthetics Consensus Committee. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: focus on the upper face. Plast Reconstr Surg. 2017; 140: 265e-276e.
14. Kashkouli MB, Abdolalizadeh P, Abolfathzadeh N, Sianati H, Sharepour M, Hadi Y. Periorbital facial rejuvenation; applied anatomy and pre-operative assessment. J Curr Ophthalmol. 2017; 29: 154-168.
15. de Maio M, Wu WTL, Goodman GJ, Monheit G (2017) Facial assessment and injection guide for Botulinum Toxin and injectable hyaluronic acid fillers: Focus on the Lower Face. Plast Reconstr Surg 140:393e–404e. https://doi.org/10.1097/PRS.0000000000003646
16. Borba A, Matayoshi S (2018) Facial rejuvenation techniques: botulinum toxin and MD Codes TM, 1st edn. Buzz Editor Ltda, Sa˜o Paulo (Brazil)
17. Kassir M, Gupta M, Galadari H et al (2020) Complications of botulinum toxin and fillers: A narrative review. J Cosmet Dermatol 19:570–573. https://doi.org/10.1111/jocd.13266
18. Sethi N, Singh S, DeBoulle K, Rahman E (2020) A review of complications due to the use of Botulinum Toxin A for cosmetic indications. Aesthetic Plast Surg. https://doi.org/10.1007/s00266-020-01983-w
19. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2019) Cochrane handbook for systematic reviews of interventions, 2nd edn. John Wiley & Sons, Chichester (UK)
20. Qaqish C (2016) Botulinum toxin use in the upper face. Atlas Oral Maxillofac Surg Clin 24:95–103. https://doi.org/10.1016/j.cxom.2016.05.006
21. Sundaram H, Signorini M, Liew S et al (2016) Global aesthetics consensus. Plast Reconstr Surg 137:518e–529e. https://doi.org/10.1097/01.prs.0000475758.63709.23
22. Jia Z, Lu H, Yang X et al (2016) Adverse events of Botulinum Toxin type A in facial rejuvenation: a systematic review and meta-analysis. Aesthetic Plast Surg 40:769–777. https://doi.org/10.1007/s00266-016-0682-1
23. Erickson BP, Lee WW, Cohen J, Grunebaum LD (2015) The role of neurotoxins in the periorbital and midfacial areas. Facial Plast Surg Clin North Am 23:243–255. https://doi.org/10.1016/j.fsc.2015.01.010
24. Sorensen EP, Urman C (2015) Cosmetic complications: rare and serious events following botulinum toxin and soft tissue filler administration. J Drugs Dermatol 14:486–491
25. Lowe NJ, Shah A, Lowe PL, Patnaik R (2010) Dosing, efficacy and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines. J Cosmet Laser Ther 12:106–111. https://doi.org/10.3109/14764170903480013
26. Abramo AC, Do Amaral TPA, Lessio BP, De Lima GA (2016) Anatomy of forehead, glabellar, nasal and orbital muscles, and their correlation with distinctive patterns of skin lines on the upper third of the face: reviewing concepts. Aesthetic Plast Surg 40:962–971. https://doi.org/10.1007/s00266-016-0712-z