PHYTOSOME: A NOVEL DRUG DELIVERY SYSTEM PREPARATION TO IMPROVE BIOAVAILABILITY OF HERBAL EXTRACT
Main Article Content
Keywords
Herbal Medicine, Phytoconstituents, Bioavailability, Phosphatidylcholine
Abstract
Herbal medicines have diverse range of active phytoconstituents provides any opportunity to use in a variety of ways, but active constituents are poorly absorbed due to their strong polarity and lipophilicity, resulting in low bioavailability. The term phytosome means complex between a natural product and natural phospholipids, like soy phospholipids that are obtained by the reaction of stoichiometric amounts of phospholipids and phytoconstituents in an appropriate solvent. Phytosomes are little cell like structure. This is a advanced form of herbal formulation which contains the bioactive phytoconstituents of plant extract surrounds and bound by lipid. Majority of the bioactive phytoconstituents are water soluble compounds like flavonoids, saponins, glucosides, terpenoids in which flavonoids are major class of bioactive phytoconstituents possess broad therapeutic uses. Phytosome shows better absorption and as a result to produce better bioavailability because it consist of water soluble herbal extract and lipophilic outer layer.
References
2. Bhupen Kalita, Malay K. Das, Anil Kumar Sharma Novel Phytosome Formulation In Making the Herbal Extract More Effective
3. Anjana Rani, Sunil Kmuar Murraya koenigii Extract Loaded Phytosomes Prepared using Antisolvent Precipitation Technique for Improved Antidiabetic and Hypolidemic Activity
4. Vishal Gaurav, Shivangi Paliwal, Arpita Singh, Swarnima Pandey, Mohd. Aqil Siddhiqui Phytosomes: Preparation, Evaluation and Application
5. Rajesh Akki1, K. Navya Sri1, K. L. Govardhani1, M. Gayatri Ramya phytosomes: a novel drug delivery for herbal extracts
6. Mei Lu ,, Qiujun Qiu , Xiang Luo , Xinrong Liu , Jing Sun , Cunyang Wang , Xiangyun Lin , Yihui Deng , Yanzhi Song Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents.
7. Nilesh Jain, Brahma P Gupta, Navneet Thakur, Ruchi Jain, Jitendra Banweer,
8. Deepak Kumar Jain, Surendra Jain Phytosome: A Novel Drug Delivery System for Herbal Medicine.
9. M. Sravanthi and J. Shiva Krishna
10. PHYTOSOMES: A NOVEL DRUG DELIVERY FOR HERBAL EXTRACTS
11. Kumar Vishal Saurabh1, Asha Kesari: Herbosomes- A Novel Carrier for Herbal Delivery. International Journal of Current Pharmaceutical Research 2011; 3:37-41.
12. Manach C, Scalbert A, Morand C. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79:727‐47.
13. Phytosomes: A technical revolution in phytomedicine. http:// www.indena.com 2010;1-7.
14. Bhattacharya S. & Ghosh A: Phytosomes-The Emerging Technology for Enhancement of Bioavailability of Botanicals and Nutraceuticals.The Internet Journal of Aesthetic and Antiaging Medicine 2009.
15. Pandey Shivanand*, Patel Kinjal: Phytosomes- Technical Revolution in Phytomedicine. International Journal of PharmTech Research 2010; 1: 627‐631.
16. Bombardelli E: Phytosome-new cosmetic delivery system. Boll Chim Farm 1991; 130 (11): 431‐38.
17. Bombardelli E, Spelta M: Phospholipid‐polyphenol complexes A new concept in skin care ingredients. Cosm & Toil 1991; 106(3): 69‐76.
18. MurrayD: Phytosomes‐ Increase the absorption of herbal extract.www.doctormurray.com/articles/silybin.htm 2008.
19. Bombardelli Ezio: Phytosome in functional cosmetics. Fitoterapia 1994; 387 – 401.
20. Magistretti Maria Jose, Bombardelli Ezio: Pharmaceutical compositions containing flavanolignans and phospholipids active principles 1997.
21. A Practical Approach: Preparation of liposomes and size determination New RRC (Ed.), Oxford University , Press 1990; 36‐39
22. Cott J. Natural Product Formulations Available in Europe for Psychotropic Indications. Psychopharmacol Bull. 1995; 31:745.
23. Bombardelli E, Curri SB, Della RL, Del NP, Tubaro A, Gariboldi P. Complexes Between Phospholipids and Vegetal Derivatives of Biological Interest. Fitoterapia. 1989; 60:1-9.
24. Dang Yi. New product concept. UPC code 0300540111783. 2000.
25. Manach C, Scalbert A, Morand C. Polyphenols: Food Sources and Bioavailability. Am J Clin Nutr. 2004; 79:727-47.
26. Mascarella S. Therapeutic and Antilipoperoxidant Effects of Silybin-Phosphatidylcholine Complex in Chronic Liver Disease, Preliminary Results. Curr Ther Res. 1993; 53:98-102.
27. Bombardelli E, Cristoni A, Morazzoni P. Phytosomes in Functional Cosmetics. Fitoterapia. 1994; 95:387-401.
28. Bombardelli E. Phytosome: New Cosmetic Delivery System. Boll Chim Farm. 1991; 130:431-38.
29. Bombardelli E, Spelta M. Phospholipid-Polyphenol Complexes: A New Concept in Skin Care Ingredients. Cosm & Toil.1991; 106:69-76.
30. Murray D. Phytosomes- Increase the Absorption of Herbal Extract [online]. 2008 [cited 2008 Sep 28]. Available from: URL: www.doctormurray.com/articles/silybin.htm
31. Phytosomes: A Technical Revolution in Phytomedicine [online]. 2010 [cited 2010 Mar 22]. Available from: URL: http://www.indena.com
32. Jose MM, Bombardelli E. Pharmaceutical Compositions Containing Flavanolignans and Phospholipida Active Principles. U.S. Patent EPO209037. 1987.
33. Sharma S, Sikarwar M. Phytosome: A Review. Planta Indica .2005;1:1-3.
34. Kidd P, Head K. A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: A Silybinphosphatidylcholine Complex. Altern Med Rev. 2005; 10:193-203.
35. Bombardelli E, Spelta M, Loggia Della R, Sosa S, Tubaro A. Aging Skin: Protective Effect of Silymarin- Phytosome. Fitoterapia. 1991; 62:115-22.
36. Bombardelli E, Mustich G. Bilobalide Phospholipid Complex, Their Uses and Formulation Containing Them. U.S. Patent EPO-275005. 1991.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Sumit das
Pharm (Pharmaceutics), Regional Institute of Paramedical and Nursing Sciences, Zemabawk, Aizawl, Mizoram -796017
Dr. H. Lalhlenmawia
Head of department (department of Pharmacy), Regional Institute of Paramedical and Nursing Sciences, Zemabawk, Aizawl, Mizoram -796017,