A LONGITUDINAL STUDY ON SERUM INSULIN-LIKE GROWTH FACTOR-I (IGF-I) LEVELS IN INFANTS AND ITS CORRELATION WITH INCIDENCE OF RETINOPATHY OF PREMATURITY.
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Keywords
Retinopathy of prematurity, preterm infant weight gain, IGF-1, postnatal growth, nutrition
Abstract
Retinopathy in premature infants is still a cause of concern in lower- and middle-income countries. Preterm infants with lesser post-natal weight gain during first 4weeks and lower serum IGF-1 level have higher incidence of ROP. This study focusses on correlation of post-natal weight gain pattern and serum IGF-1 level with incidence of ROP among South Indian population. It included two cohorts of preterm infants with and without ROP ≤32 weeks gestational age / ≤1500gm birth weight. Serum IGF-I levels were measured at the end of 28days. Data was analysed to observe significant difference in mean weight gain pattern of with and without ROP group. The cohort without ROP had a better weight gain pattern and better IGF-1 levels as compared to the cohort with ROP. Weight gain was shown to be an independent predictor (p value: 0.012) after comparing the various other risk factors by logistic regression. The mean duration of age of reaching full feeds in the two groups shows a significant difference {15.57(6.204) in the group without ROP as compared to 19.62(6.775) in the group with ROP} p= 0.008. Mean serum IGF-1 levels of the two cohorts signified that the cohort without ROP had better serum IGF-1 levels as compared to the cohort with ROP. Cumulative weight gain was the only independent risk factors for severe ROP. Thereby, promotion of postnatal growth and weight gain along with optimal nutrition might prevent proliferative ROP in infants.
References
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Dr. Raghu T Gokhale
Junior Resident, Department of Pediatrics, Ramaiah Medical College
Dr. Pradeep GCM
Professor of Pediatrics, Ramaiah Medical College
Dr. Krithika MV
Assistant Professor, Ramaiah Medical College
Dr. Sharanabasavesh M
Associate Professor, Ramaiah Medical College,
Dr. Mallikarjuna B
Professor of Pediatrics, Ramaiah Medical College, Bangalore